2gdw: Difference between revisions

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-{{Seed}}
-[[Image:2gdw.png|left|200px]]
-<!--
+==Solution structure of the B. brevis TycC3-PCP in A/H-state==
-The line below this paragraph, containing "STRUCTURE_2gdw", creates the "Structure Box" on the page.
+<StructureSection load='2gdw' size='340' side='right'caption='[[2gdw]]' scene=''>
-You may change the PDB parameter (which sets the PDB file loaded into the applet)
+== Structural highlights ==
-or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+<table><tr><td colspan='2'>[[2gdw]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Brevibacillus_parabrevis Brevibacillus parabrevis]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GDW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2GDW FirstGlance]. <br>
-or leave the SCENE parameter empty for the default display.
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
--->
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2gdw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2gdw OCA], [https://pdbe.org/2gdw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2gdw RCSB], [https://www.ebi.ac.uk/pdbsum/2gdw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2gdw ProSAT]</span></td></tr>
-{{STRUCTURE_2gdw|  PDB=2gdw  |  SCENE=  }}
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/TYCC_BREPA TYCC_BREPA] Incorporates six amino acids (for tyrocidine A, Asn, Gln, Tyr, Val, Orn, and Leu) in their L-configuration into the peptide product.
+== Evolutionary Conservation ==
+[[Image:Consurf_key_small.gif|200px|right]]
+Check<jmol>
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/gd/2gdw_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2gdw ConSurf].
+<div style="clear:both"></div>
+<div style="background-color:#fffaf0;">
+== Publication Abstract from PubMed ==
+Protein dynamics plays an important role in protein function. Many functionally important motions occur on the microsecond and low millisecond time scale and can be characterized by nuclear magnetic resonance relaxation experiments. We describe the different states of a peptidyl carrier protein (PCP) that play a crucial role in its function as a peptide shuttle in the nonribosomal peptide synthetases of the tyrocidine A system. Both apo-PCP (without the bound 4'-phosphopantetheine cofactor) and holo-PCP exist in two different stable conformations. We show that one of the apo conformations and one of the holo conformations are identical, whereas the two remaining conformations are only detectable by nuclear magnetic resonance spectroscopy in either the apo or holo form. We further demonstrate that this conformational diversity is an essential prerequisite for the directed movement of the 4'-PP cofactor and its interaction with externally acting proteins such as thioesterases and 4'-PP transferase.
-===Solution structure of the B. brevis TycC3-PCP in A/H-state===
+Conformational switches modulate protein interactions in peptide antibiotic synthetases.,Koglin A, Mofid MR, Lohr F, Schafer B, Rogov VV, Blum MM, Mittag T, Marahiel MA, Bernhard F, Dotsch V Science. 2006 Apr 14;312(5771):273-6. PMID:16614225<ref>PMID:16614225</ref>
+From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
-<!--
+</div>
-The line below this paragraph, {{ABSTRACT_PUBMED_16614225}}, adds the Publication Abstract to the page
+<div class="pdbe-citations 2gdw" style="background-color:#fffaf0;"></div>
-(as it appears on PubMed at http://www.pubmed.gov), where 16614225 is the PubMed ID number.
+== References ==
--->
+<references/>
-{{ABSTRACT_PUBMED_16614225}}
+__TOC__
+</StructureSection>
-==About this Structure==
-GDW is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Brevibacillus_parabrevis Brevibacillus parabrevis]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GDW OCA].
-==Reference==
-<ref group="xtra">PMID:16614225</ref><references group="xtra"/>
 [[Category: Brevibacillus parabrevis]]
-[[Category: Bernhard, F.]]
+[[Category: Large Structures]]
-[[Category: Doetsch, V.]]
+[[Category: Bernhard F]]
-[[Category: Koglin, A.]]
+[[Category: Doetsch V]]
-[[Category: Loehr, F.]]
+[[Category: Koglin A]]
-[[Category: Marahiel, M A.]]
+[[Category: Loehr F]]
-[[Category: Rogov, V V.]]
+[[Category: Marahiel MA]]
-[[Category: Three-helix bundle]]
+[[Category: Rogov VV]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 14:07:05 2009''