2g2k: Difference between revisions

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==NMR structure of an N-terminal fragment of the eukaryotic initiation factor 5 (eIF5)==
==NMR structure of an N-terminal fragment of the eukaryotic initiation factor 5 (eIF5)==
<StructureSection load='2g2k' size='340' side='right'caption='[[2g2k]], [[NMR_Ensembles_of_Models | 18 NMR models]]' scene=''>
<StructureSection load='2g2k' size='340' side='right'caption='[[2g2k]]' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[2g2k]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2G2K OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2G2K FirstGlance]. <br>
<table><tr><td colspan='2'>[[2g2k]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2G2K OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2G2K FirstGlance]. <br>
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2g2k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2g2k OCA], [https://pdbe.org/2g2k PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2g2k RCSB], [https://www.ebi.ac.uk/pdbsum/2g2k PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2g2k ProSAT]</span></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2g2k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2g2k OCA], [https://pdbe.org/2g2k PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2g2k RCSB], [https://www.ebi.ac.uk/pdbsum/2g2k PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2g2k ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[https://www.uniprot.org/uniprot/IF5_HUMAN IF5_HUMAN]] Catalyzes the hydrolysis of GTP bound to the 40S ribosomal initiation complex (40S.mRNA.Met-tRNA[F].eIF-2.GTP) with the subsequent joining of a 60S ribosomal subunit resulting in the release of eIF-2 and the guanine nucleotide. The subsequent joining of a 60S ribosomal subunit results in the formation of a functional 80S initiation complex (80S.mRNA.Met-tRNA[F]).  
[https://www.uniprot.org/uniprot/IF5_HUMAN IF5_HUMAN] Catalyzes the hydrolysis of GTP bound to the 40S ribosomal initiation complex (40S.mRNA.Met-tRNA[F].eIF-2.GTP) with the subsequent joining of a 60S ribosomal subunit resulting in the release of eIF-2 and the guanine nucleotide. The subsequent joining of a 60S ribosomal subunit results in the formation of a functional 80S initiation complex (80S.mRNA.Met-tRNA[F]).
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Human]]
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Babon, J]]
[[Category: Babon J]]
[[Category: Conte, M R]]
[[Category: Conte MR]]
[[Category: Kelly, G]]
[[Category: Kelly G]]
[[Category: Proud, C G]]
[[Category: Proud CG]]
[[Category: Sanfelice, D]]
[[Category: Sanfelice D]]
[[Category: Smerdon, S J]]
[[Category: Smerdon SJ]]
[[Category: Eif125 fold]]
[[Category: Eif5]]
[[Category: Translation]]

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