2fc8: Difference between revisions

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-[[Image:2fc8.gif|left|200px]]
- {{Structure
+==Solution structure of the RRM_1 domain of NCL protein==
-|PDB= 2fc8 |SIZE=350|CAPTION= <scene name='initialview01'>2fc8</scene>
+<StructureSection load='2fc8' size='340' side='right'caption='[[2fc8]]' scene=''>
-|SITE=
+== Structural highlights ==
-|LIGAND=
+<table><tr><td colspan='2'>[[2fc8]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FC8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2FC8 FirstGlance]. <br>
-|ACTIVITY=
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
-|GENE=
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2fc8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2fc8 OCA], [https://pdbe.org/2fc8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2fc8 RCSB], [https://www.ebi.ac.uk/pdbsum/2fc8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2fc8 ProSAT], [https://www.topsan.org/Proteins/RSGI/2fc8 TOPSAN]</span></td></tr>
-}}
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/NUCL_HUMAN NUCL_HUMAN] Nucleolin is the major nucleolar protein of growing eukaryotic cells. It is found associated with intranucleolar chromatin and pre-ribosomal particles. It induces chromatin decondensation by binding to histone H1. It is thought to play a role in pre-rRNA transcription and ribosome assembly. May play a role in the process of transcriptional elongation. Binds RNA oligonucleotides with 5'-UUAGGG-3' repeats more tightly than the telomeric single-stranded DNA 5'-TTAGGG-3' repeats.<ref>PMID:10393184</ref>
+== Evolutionary Conservation ==
+[[Image:Consurf_key_small.gif|200px|right]]
+Check<jmol>
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/fc/2fc8_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2fc8 ConSurf].
+<div style="clear:both"></div>
-'''Solution structure of the RRM_1 domain of NCL protein'''
+==See Also==
+*[[Nucleolin|Nucleolin]]
+== References ==
-==About this Structure==
+<references/>
-FC8 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FC8 OCA].
+__TOC__
+</StructureSection>
 [[Category: Homo sapiens]]
-[[Category: Single protein]]
+[[Category: Large Structures]]
-[[Category: Dang, W.]]
+[[Category: Dang W]]
-[[Category: Inoue, M.]]
+[[Category: Inoue M]]
-[[Category: Kigawa, T.]]
+[[Category: Kigawa T]]
-[[Category: Muto, Y.]]
+[[Category: Muto Y]]
-[[Category: RSGI, RIKEN Structural Genomics/Proteomics Initiative.]]
+[[Category: Shirouzu M]]
-[[Category: Shirouzu, M.]]
+[[Category: Terada T]]
-[[Category: Terada, T.]]
+[[Category: Yokoyama S]]
-[[Category: Yokoyama, S.]]
-[[Category: national project on protein structural and functional analyse]]
-[[Category: ncl protein]]
-[[Category: nmr]]
-[[Category: nppsfa]]
-[[Category: riken structural genomics/proteomics initiative]]
-[[Category: rrm_1 domain]]
-[[Category: rsgi]]
-[[Category: structural genomic]]
-[[Category: structure genomic]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 16:50:37 2008''