2f2d: Difference between revisions

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-[[Image:2f2d.gif|left|200px]]
- {{Structure
+==Solution structure of the FK506-binding domain of human FKBP38==
-|PDB= 2f2d |SIZE=350|CAPTION= <scene name='initialview01'>2f2d</scene>
+<StructureSection load='2f2d' size='340' side='right'caption='[[2f2d]]' scene=''>
-|SITE=
+== Structural highlights ==
-|LIGAND=
+<table><tr><td colspan='2'>[[2f2d]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2F2D OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2F2D FirstGlance]. <br>
-|ACTIVITY=
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
-|GENE= FKBP8, FKBP38 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2f2d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2f2d OCA], [https://pdbe.org/2f2d PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2f2d RCSB], [https://www.ebi.ac.uk/pdbsum/2f2d PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2f2d ProSAT]</span></td></tr>
-}}
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/FKBP8_HUMAN FKBP8_HUMAN] Constitutively inactive PPiase, which becomes active when bound to calmodulin and calcium. Seems to act as a chaperone for BCL2, targets it to the mitochondria and modulates its phosphorylation state. The BCL2/FKBP8/calmodulin/calcium complex probably interferes with the binding of BCL2 to its targets. The active form of FKBP8 may therefore play a role in the regulation of apoptosis.<ref>PMID:12510191</ref> <ref>PMID:16176796</ref> <ref>PMID:15757646</ref>
+== Evolutionary Conservation ==
+[[Image:Consurf_key_small.gif|200px|right]]
+Check<jmol>
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/f2/2f2d_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2f2d ConSurf].
+<div style="clear:both"></div>
-'''Solution structure of the FK506-binding domain of human FKBP38'''
+==See Also==
+*[[FKBP 3D structures|FKBP 3D structures]]
+== References ==
-==About this Structure==
+<references/>
-F2D is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2F2D OCA].
+__TOC__
+</StructureSection>
-==Reference==
-Solution structure of the FK506-binding domain of human FKBP38., Maestre-Martinez M, Edlich F, Jarczowski F, Weiwad M, Fischer G, Lucke C, J Biomol NMR. 2006 Mar;34(3):197-202. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16604427 16604427]
 [[Category: Homo sapiens]]
-[[Category: Single protein]]
+[[Category: Large Structures]]
-[[Category: Edlich, F.]]
+[[Category: Edlich F]]
-[[Category: Fischer, G.]]
+[[Category: Fischer G]]
-[[Category: Jarczowski, F.]]
+[[Category: Jarczowski F]]
-[[Category: Luecke, C.]]
+[[Category: Luecke C]]
-[[Category: Maestre-Martinez, M.]]
+[[Category: Maestre-Martinez M]]
-[[Category: Weiwad, M.]]
+[[Category: Weiwad M]]
-[[Category: beta half-barrel]]
-[[Category: immunophilin]]
-[[Category: ppiase]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 16:47:23 2008''