2epr: Difference between revisions

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{{Seed}}
[[Image:2epr.png|left|200px]]


<!--
==Solution structure of the secound zinc finger domain of Zinc finger protein 278==
The line below this paragraph, containing "STRUCTURE_2epr", creates the "Structure Box" on the page.
<StructureSection load='2epr' size='340' side='right'caption='[[2epr]]' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[2epr]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2EPR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2EPR FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
-->
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
{{STRUCTURE_2epr|  PDB=2epr  |  SCENE=  }}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2epr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2epr OCA], [https://pdbe.org/2epr PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2epr RCSB], [https://www.ebi.ac.uk/pdbsum/2epr PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2epr ProSAT], [https://www.topsan.org/Proteins/RSGI/2epr TOPSAN]</span></td></tr>
 
</table>
===Solution structure of the secound zinc finger domain of Zinc finger protein 278===
== Disease ==
 
[https://www.uniprot.org/uniprot/PATZ1_HUMAN PATZ1_HUMAN] Note=A chromosomal aberration involving PATZ1 is associated with small round cell sarcoma. Translocation t(1;22)(p36.1;q12) with EWSR1.
 
== Function ==
==About this Structure==
[https://www.uniprot.org/uniprot/PATZ1_HUMAN PATZ1_HUMAN] Transcriptional repressor.<ref>PMID:10713105</ref>
2EPR is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2EPR OCA].  
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ep/2epr_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2epr ConSurf].
<div style="clear:both"></div>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Inoue, M.]]
[[Category: Large Structures]]
[[Category: Kigawa, T.]]
[[Category: Inoue M]]
[[Category: Muto, Y.]]
[[Category: Kigawa T]]
[[Category: RSGI, RIKEN Structural Genomics/Proteomics Initiative.]]
[[Category: Muto Y]]
[[Category: Shirouzu, M.]]
[[Category: Shirouzu M]]
[[Category: Suzuki, S.]]
[[Category: Suzuki S]]
[[Category: Tanabe, W.]]
[[Category: Tanabe W]]
[[Category: Terada, T.]]
[[Category: Terada T]]
[[Category: Yokoyama, S.]]
[[Category: Yokoyama S]]
[[Category: C2h2]]
[[Category: National project on protein structural and functional analyse]]
[[Category: Nppsfa]]
[[Category: Riken structural genomics/proteomics initiative]]
[[Category: Rsgi]]
[[Category: Structural genomic]]
[[Category: Transcription]]
[[Category: Zinc finger domain]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Nov 16 12:30:03 2008''

Latest revision as of 21:54, 29 May 2024

Solution structure of the secound zinc finger domain of Zinc finger protein 278Solution structure of the secound zinc finger domain of Zinc finger protein 278

Structural highlights

2epr is a 1 chain structure with sequence from Homo sapiens. Full experimental information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:Solution NMR
Ligands:
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT, TOPSAN

Disease

PATZ1_HUMAN Note=A chromosomal aberration involving PATZ1 is associated with small round cell sarcoma. Translocation t(1;22)(p36.1;q12) with EWSR1.

Function

PATZ1_HUMAN Transcriptional repressor.[1]

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

References

  1. ↑ Fedele M, Benvenuto G, Pero R, Majello B, Battista S, Lembo F, Vollono E, Day PM, Santoro M, Lania L, Bruni CB, Fusco A, Chiariotti L. A novel member of the BTB/POZ family, PATZ, associates with the RNF4 RING finger protein and acts as a transcriptional repressor. J Biol Chem. 2000 Mar 17;275(11):7894-901. PMID:10713105
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