2epd: Difference between revisions

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[[Image:2epd.jpg|left|200px]]


{{Structure
==Solution structure of SH3 domain in Rho-GTPase-activating protein 4==
|PDB= 2epd |SIZE=350|CAPTION= <scene name='initialview01'>2epd</scene>
<StructureSection load='2epd' size='340' side='right'caption='[[2epd]]' scene=''>
|SITE=  
== Structural highlights ==
|LIGAND=  
<table><tr><td colspan='2'>[[2epd]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2EPD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2EPD FirstGlance]. <br>
|ACTIVITY=  
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
|GENE= ARHGAP4, KIAA0131, RGC1, RHOGAP4 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2epd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2epd OCA], [https://pdbe.org/2epd PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2epd RCSB], [https://www.ebi.ac.uk/pdbsum/2epd PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2epd ProSAT], [https://www.topsan.org/Proteins/RSGI/2epd TOPSAN]</span></td></tr>
}}
</table>
== Function ==
[https://www.uniprot.org/uniprot/RHG04_HUMAN RHG04_HUMAN] Inhibitory effect on stress fiber organization. May down-regulate Rho-like GTPase in hematopoietic cells.
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ep/2epd_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2epd ConSurf].
<div style="clear:both"></div>


'''Solution structure of SH3 domain in Rho-GTPase-activating protein 4'''
==See Also==
 
*[[Rho GTPase activating protein 3D structures|Rho GTPase activating protein 3D structures]]
 
__TOC__
==About this Structure==
</StructureSection>
2EPD is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2EPD OCA].
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Single protein]]
[[Category: Large Structures]]
[[Category: Inoue, M.]]
[[Category: Inoue M]]
[[Category: Kigawa, T.]]
[[Category: Kigawa T]]
[[Category: Muto, Y.]]
[[Category: Muto Y]]
[[Category: RSGI, RIKEN Structural Genomics/Proteomics Initiative.]]
[[Category: Shirouzu M]]
[[Category: Shirouzu, M.]]
[[Category: Tanabe W]]
[[Category: Tanabe, W.]]
[[Category: Terada T]]
[[Category: Terada, T.]]
[[Category: Tsuda K]]
[[Category: Tsuda, K.]]
[[Category: Yokoyama S]]
[[Category: Yokoyama, S.]]
[[Category: national project on protein structural and functional analyse]]
[[Category: nppsfa]]
[[Category: protein binding]]
[[Category: riken structural genomics/proteomics initiative]]
[[Category: rsgi]]
[[Category: sh3 domain]]
[[Category: structural genomic]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 16:42:56 2008''

Latest revision as of 21:54, 29 May 2024

Solution structure of SH3 domain in Rho-GTPase-activating protein 4Solution structure of SH3 domain in Rho-GTPase-activating protein 4

Structural highlights

2epd is a 1 chain structure with sequence from Homo sapiens. Full experimental information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:Solution NMR
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT, TOPSAN

Function

RHG04_HUMAN Inhibitory effect on stress fiber organization. May down-regulate Rho-like GTPase in hematopoietic cells.

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

See Also

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA
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