2enm: Difference between revisions

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-[[Image:2enm.jpg|left|200px]]<br /><applet load="2enm" size="350" color="white" frame="true" align="right" spinBox="true"
-caption="2enm" />
-'''Solution structure of the SH3 domain from mouse sorting nexin-9'''<br />
-==About this Structure==
+==Solution structure of the SH3 domain from mouse sorting nexin-9==
-ENM is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ENM OCA].
+<StructureSection load='2enm' size='340' side='right'caption='[[2enm]]' scene=''>
+== Structural highlights ==
+<table><tr><td colspan='2'>[[2enm]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ENM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2ENM FirstGlance]. <br>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2enm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2enm OCA], [https://pdbe.org/2enm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2enm RCSB], [https://www.ebi.ac.uk/pdbsum/2enm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2enm ProSAT], [https://www.topsan.org/Proteins/RSGI/2enm TOPSAN]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/SNX9_MOUSE SNX9_MOUSE] May be involved in several stages of intracellular trafficking. Plays a role in endocytosis via clathrin-coated pits, but also clathrin-independent, actin-dependent fluid-phase endocytosis. Plays a role in macropinocytosis. Promotes internalization of TNFR. Promotes degradation of EGFR after EGF signaling. Stimulates the GTPase activity of DNM1. Promotes DNM1 oligomerization. Promotes activation of the Arp2/3 complex by WASL, and thereby plays a role in the reorganization of the F-actin cytoskeleton. Binds to membranes enriched in phosphatidylinositol 4,5-bisphosphate and promotes membrane tubulation. Has lower affinity for membranes enriched in phosphatidylinositol 3-phosphate (By similarity).
+== Evolutionary Conservation ==
+[[Image:Consurf_key_small.gif|200px|right]]
+Check<jmol>
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/en/2enm_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2enm ConSurf].
+<div style="clear:both"></div>
+==See Also==
+*[[Sorting nexin 3D structures|Sorting nexin 3D structures]]
+__TOC__
+</StructureSection>
+[[Category: Large Structures]]
 [[Category: Mus musculus]]
-[[Category: Single protein]]
+[[Category: Hayashi F]]
-[[Category: Hayashi, F.]]
+[[Category: Kurosaki C]]
-[[Category: Kurosaki, C.]]
+[[Category: Wakabayashi M]]
-[[Category: RSGI, RIKEN Structural Genomics/Proteomics Initiative.]]
+[[Category: Yokoyama S]]
-[[Category: Wakabayashi, M.]]
+[[Category: Yoshida M]]
-[[Category: Yokoyama, S.]]
-[[Category: Yoshida, M.]]
-[[Category: endocytosis]]
-[[Category: national project on protein structural and functional analyses]]
-[[Category: nppsfa]]
-[[Category: protein transport]]
-[[Category: riken structural genomics/proteomics initiative]]
-[[Category: rsgi]]
-[[Category: sh3-like barrel]]
-[[Category: structural genomics]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 17:12:52 2008''