2emc: Difference between revisions

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-[[Image:2emc.jpg|left|200px]]
- {{Structure
+==Solution structure of the C2H2 type zinc finger (region 641-673) of human Zinc finger protein 473==
-|PDB= 2emc |SIZE=350|CAPTION= <scene name='initialview01'>2emc</scene>
+<StructureSection load='2emc' size='340' side='right'caption='[[2emc]]' scene=''>
-|SITE=
+== Structural highlights ==
-|LIGAND= <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene>
+<table><tr><td colspan='2'>[[2emc]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2EMC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2EMC FirstGlance]. <br>
-|ACTIVITY=
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
-|GENE= ZNF473 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-|DOMAIN=
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2emc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2emc OCA], [https://pdbe.org/2emc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2emc RCSB], [https://www.ebi.ac.uk/pdbsum/2emc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2emc ProSAT], [https://www.topsan.org/Proteins/RSGI/2emc TOPSAN]</span></td></tr>
-|RELATEDENTRY=
+</table>
-|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2emc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2emc OCA], [http://www.ebi.ac.uk/pdbsum/2emc PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2emc RCSB]</span>
+== Function ==
-}}
+[https://www.uniprot.org/uniprot/ZN473_HUMAN ZN473_HUMAN] Involved in histone 3'-end pre-mRNA processing by associating with U7 snRNP and interacting with SLBP/pre-mRNA complex. Increases histone 3'-end pre-mRNA processing but has no effect on U7 snRNP levels, when overexpressed. Required for cell cycle progression from G1 to S phases.<ref>PMID:11782445</ref> <ref>PMID:16914750</ref> <ref>PMID:16714279</ref>
+== Evolutionary Conservation ==
-'''Solution structure of the C2H2 type zinc finger (region 641-673) of human Zinc finger protein 473'''
+[[Image:Consurf_key_small.gif|200px|right]]
+Check<jmol>
+  <jmolCheckbox>
-==About this Structure==
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/em/2emc_consurf.spt"</scriptWhenChecked>
-EMC is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2EMC OCA].
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2emc ConSurf].
+<div style="clear:both"></div>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
 [[Category: Homo sapiens]]
-[[Category: Single protein]]
+[[Category: Large Structures]]
-[[Category: Abe, H.]]
+[[Category: Abe H]]
-[[Category: Kigawa, T.]]
+[[Category: Kigawa T]]
-[[Category: Kobayashi, N.]]
+[[Category: Kobayashi N]]
-[[Category: Koshiba, S.]]
+[[Category: Koshiba S]]
-[[Category: Li, H.]]
+[[Category: Li H]]
-[[Category: RSGI, RIKEN Structural Genomics/Proteomics Initiative.]]
+[[Category: Saito K]]
-[[Category: Saito, K.]]
+[[Category: Sato M]]
-[[Category: Sato, M.]]
+[[Category: Tochio N]]
-[[Category: Tochio, N.]]
+[[Category: Tomizawa T]]
-[[Category: Tomizawa, T.]]
+[[Category: Yokoyama S]]
-[[Category: Yokoyama, S.]]
-[[Category: national project on protein structural and functional analyse]]
-[[Category: nmr]]
-[[Category: nppsfa]]
-[[Category: riken structural genomics/proteomics initiative]]
-[[Category: rsgi]]
-[[Category: structural genomic]]
-[[Category: transcription]]
-[[Category: zf-c2h2]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 02:51:01 2008''