2edi: Difference between revisions

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-[[Image:2edi.jpg|left|200px]]
- {{Structure
+==Solution structure of the UQ_con domain from human NEDD8-conjugating enzyme NCE2==
-|PDB= 2edi |SIZE=350|CAPTION= <scene name='initialview01'>2edi</scene>
+<StructureSection load='2edi' size='340' side='right'caption='[[2edi]]' scene=''>
-|SITE=
+== Structural highlights ==
-|LIGAND=
+<table><tr><td colspan='2'>[[2edi]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2EDI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2EDI FirstGlance]. <br>
-|ACTIVITY=
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
-|GENE= NCE2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2edi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2edi OCA], [https://pdbe.org/2edi PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2edi RCSB], [https://www.ebi.ac.uk/pdbsum/2edi PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2edi ProSAT], [https://www.topsan.org/Proteins/RSGI/2edi TOPSAN]</span></td></tr>
-}}
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/UBE2F_HUMAN UBE2F_HUMAN] Accepts the ubiquitin-like protein NEDD8 from the UBA3-NAE1 E1 complex and catalyzes its covalent attachment to other proteins. The specific interaction with the E3 ubiquitin ligase RBX2, but not RBX1, suggests that the RBX2-UBE2F complex neddylates specific target proteins, such as CUL5.
+== Evolutionary Conservation ==
+[[Image:Consurf_key_small.gif|200px|right]]
+Check<jmol>
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ed/2edi_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2edi ConSurf].
+<div style="clear:both"></div>
-'''Solution structure of the UQ_con domain from human NEDD8-conjugating enzyme NCE2'''
+==See Also==
+*[[3D structures of ubiquitin conjugating enzyme|3D structures of ubiquitin conjugating enzyme]]
+__TOC__
-==About this Structure==
+</StructureSection>
-EDI is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2EDI OCA].
 [[Category: Homo sapiens]]
-[[Category: Single protein]]
+[[Category: Large Structures]]
-[[Category: Endo, H.]]
+[[Category: Endo H]]
-[[Category: Hayashi, F.]]
+[[Category: Hayashi F]]
-[[Category: Izumi, K.]]
+[[Category: Izumi K]]
-[[Category: RSGI, RIKEN Structural Genomics/Proteomics Initiative.]]
+[[Category: Yokoyama S]]
-[[Category: Yokoyama, S.]]
+[[Category: Yoshida M]]
-[[Category: Yoshida, M.]]
-[[Category: e2 conjugating enzyme]]
-[[Category: ligase]]
-[[Category: national project on protein structural and functional analyse]]
-[[Category: non-proline cis peptide bond]]
-[[Category: nppsfa]]
-[[Category: riken structural genomics/proteomics initiative]]
-[[Category: rsgi]]
-[[Category: structural genomic]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 16:38:38 2008''