2ed7: Difference between revisions

← Older edit

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA

@@ Line 1: / Line 1: @@
-[[Image:2ed7.jpg|left|200px]]
- {{Structure
+==Solution structure of the first fibronectin type III domain of human Netrin receptor DCC==
-|PDB= 2ed7 |SIZE=350|CAPTION= <scene name='initialview01'>2ed7</scene>
+<StructureSection load='2ed7' size='340' side='right'caption='[[2ed7]]' scene=''>
-|SITE=
+== Structural highlights ==
-|LIGAND=
+<table><tr><td colspan='2'>[[2ed7]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ED7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2ED7 FirstGlance]. <br>
-|ACTIVITY=
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
-|GENE= DCC ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ed7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ed7 OCA], [https://pdbe.org/2ed7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ed7 RCSB], [https://www.ebi.ac.uk/pdbsum/2ed7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ed7 ProSAT], [https://www.topsan.org/Proteins/RSGI/2ed7 TOPSAN]</span></td></tr>
-|DOMAIN=
+</table>
-|RELATEDENTRY=
+== Disease ==
-|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ed7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ed7 OCA], [http://www.ebi.ac.uk/pdbsum/2ed7 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2ed7 RCSB]</span>
+[https://www.uniprot.org/uniprot/DCC_HUMAN DCC_HUMAN] Defects in DCC are the cause of mirror movements type 1 (MRMV1) [MIM:[https://omim.org/entry/157600 157600]. A disorder characterized by contralateral involuntary movements that mirror voluntary ones. While mirror movements are occasionally found in young children, persistence beyond the age of 10 is abnormal. Mirror movements occur more commonly in the upper extremities.<ref>PMID:20431009</ref>
-}}
+== Function ==
+[https://www.uniprot.org/uniprot/DCC_HUMAN DCC_HUMAN] Receptor for netrin required for axon guidance. Mediates axon attraction of neuronal growth cones in the developing nervous system upon ligand binding. Its association with UNC5 proteins may trigger signaling for axon repulsion. It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand. Implicated as a tumor suppressor gene.<ref>PMID:8861902</ref> <ref>PMID:8187090</ref>
+== Evolutionary Conservation ==
+[[Image:Consurf_key_small.gif|200px|right]]
+Check<jmol>
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ed/2ed7_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2ed7 ConSurf].
+<div style="clear:both"></div>
-'''Solution structure of the first fibronectin type III domain of human Netrin receptor DCC'''
+==See Also==
+*[[Netrin receptor|Netrin receptor]]
+== References ==
-==Disease==
+<references/>
-Known disease associated with this structure: Colorectal cancer OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=120470 120470]]
+__TOC__
+</StructureSection>
-==About this Structure==
-ED7 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ED7 OCA].
 [[Category: Homo sapiens]]
-[[Category: Single protein]]
+[[Category: Large Structures]]
-[[Category: Kigawa, T.]]
+[[Category: Kigawa T]]
-[[Category: Koshiba, S.]]
+[[Category: Koshiba S]]
-[[Category: RSGI, RIKEN Structural Genomics/Proteomics Initiative.]]
+[[Category: Tochio N]]
-[[Category: Tochio, N.]]
+[[Category: Tomizawa T]]
-[[Category: Tomizawa, T.]]
+[[Category: Yokoyama S]]
-[[Category: Yokoyama, S.]]
-[[Category: apoptosis]]
-[[Category: colorectal cancer suppressor]]
-[[Category: national project on protein structural and functional analyse]]
-[[Category: nppsfa]]
-[[Category: riken structural genomics/proteomics initiative]]
-[[Category: rsgi]]
-[[Category: structural genomic]]
-[[Category: tumor suppressor protein dcc]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 02:47:18 2008''