2ecl: Difference between revisions

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 ==Solution Structure of the RING domain of the human RING-box protein 2==
-<StructureSection load='2ecl' size='340' side='right' caption='[[2ecl]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
+<StructureSection load='2ecl' size='340' side='right'caption='[[2ecl]]' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[2ecl]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ECL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ECL FirstGlance]. <br>
+<table><tr><td colspan='2'>[[2ecl]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ECL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2ECL FirstGlance]. <br>
-</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene><br>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
-<tr><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">RNF7 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ecl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ecl OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2ecl RCSB], [http://www.ebi.ac.uk/pdbsum/2ecl PDBsum], [http://www.topsan.org/Proteins/RSGI/2ecl TOPSAN]</span></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ecl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ecl OCA], [https://pdbe.org/2ecl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ecl RCSB], [https://www.ebi.ac.uk/pdbsum/2ecl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ecl ProSAT], [https://www.topsan.org/Proteins/RSGI/2ecl TOPSAN]</span></td></tr>
-<table>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/RBX2_HUMAN RBX2_HUMAN] Probable component of the SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins involved in cell cycle progression, signal transduction and transcription. Through the RING-type zinc finger, seems to recruit the E2 ubiquitination enzyme to the complex and brings it into close proximity to the substrate. Promotes the neddylation of CUL5 via its interaction with UBE2F. May play a role in protecting cells from apoptosis induced by redox agents.<ref>PMID:10851089</ref>
 == Evolutionary Conservation ==
 [[Image:Consurf_key_small.gif|200px|right]]
 Check<jmol>
    <jmolCheckbox>
-     <scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ec/2ecl_consurf.spt"</scriptWhenChecked>
+     <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ec/2ecl_consurf.spt"</scriptWhenChecked>
      <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
      <text>to colour the structure by Evolutionary Conservation</text>
    </jmolCheckbox>
-</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2ecl ConSurf].
 <div style="clear:both"></div>
+==See Also==
+*[[Ring box protein 3D structures|Ring box protein 3D structures]]
+== References ==
+<references/>
 __TOC__
 </StructureSection>
 [[Category: Homo sapiens]]
-[[Category: Harada, T.]]
+[[Category: Large Structures]]
-[[Category: Kigawa, T.]]
+[[Category: Harada T]]
-[[Category: Koshiba, S.]]
+[[Category: Kigawa T]]
-[[Category: Miyamoto, K.]]
+[[Category: Koshiba S]]
-[[Category: RSGI, RIKEN Structural Genomics/Proteomics Initiative.]]
+[[Category: Miyamoto K]]
-[[Category: Tomizawa, T.]]
+[[Category: Tomizawa T]]
-[[Category: Watanabe, S.]]
+[[Category: Watanabe S]]
-[[Category: Yokoyama, S.]]
+[[Category: Yokoyama S]]
-[[Category: Metal binding protein]]
-[[Category: National project on protein structural and functional analyse]]
-[[Category: Nppsfa]]
-[[Category: Riken structural genomics/proteomics initiative]]
-[[Category: Ring domian]]
-[[Category: Ring-box protein 2]]
-[[Category: Rnf7]]
-[[Category: Rsgi]]
-[[Category: Structural genomic]]
-[[Category: Zinc-binding domain]]