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==Solution structure of three tandem repeats of zf-C2H2 domains from human Kruppel-like factor 5==
==Solution structure of three tandem repeats of zf-C2H2 domains from human Kruppel-like factor 5==
<StructureSection load='2ebt' size='340' side='right'caption='[[2ebt]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
<StructureSection load='2ebt' size='340' side='right'caption='[[2ebt]]' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[2ebt]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. The April 2009 RCSB PDB [http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/index.html Molecule of the Month] feature on ''Oct and Sox Transcription Factors''  by David Goodsell is [http://dx.doi.org/10.2210/rcsb_pdb/mom_2009_4 10.2210/rcsb_pdb/mom_2009_4]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2EBT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2EBT FirstGlance]. <br>
<table><tr><td colspan='2'>[[2ebt]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. The April 2009 RCSB PDB [https://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/index.html Molecule of the Month] feature on ''Oct and Sox Transcription Factors''  by David Goodsell is [https://dx.doi.org/10.2210/rcsb_pdb/mom_2009_4 10.2210/rcsb_pdb/mom_2009_4]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2EBT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2EBT FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ebt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ebt OCA], [http://pdbe.org/2ebt PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2ebt RCSB], [http://www.ebi.ac.uk/pdbsum/2ebt PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2ebt ProSAT], [http://www.topsan.org/Proteins/RSGI/2ebt TOPSAN]</span></td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ebt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ebt OCA], [https://pdbe.org/2ebt PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ebt RCSB], [https://www.ebi.ac.uk/pdbsum/2ebt PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ebt ProSAT], [https://www.topsan.org/Proteins/RSGI/2ebt TOPSAN]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/KLF5_HUMAN KLF5_HUMAN]] Transcription factor that binds to GC box promoter elements. Activates the transcription of these genes.  
[https://www.uniprot.org/uniprot/KLF5_HUMAN KLF5_HUMAN] Transcription factor that binds to GC box promoter elements. Activates the transcription of these genes.
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2ebt ConSurf].
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2ebt ConSurf].
<div style="clear:both"></div>
<div style="clear:both"></div>
==See Also==
*[[Teaching Scenes%2C Tutorials%2C and Educators' Pages|Teaching Scenes%2C Tutorials%2C and Educators' Pages]]
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Human]]
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Oct and Sox Transcription Factors]]
[[Category: Oct and Sox Transcription Factors]]
[[Category: RCSB PDB Molecule of the Month]]
[[Category: RCSB PDB Molecule of the Month]]
[[Category: Hayashi, F]]
[[Category: Hayashi F]]
[[Category: Nagashima, T]]
[[Category: Nagashima T]]
[[Category: Structural genomic]]
[[Category: Yokoyama S]]
[[Category: Yokoyama, S]]
[[Category: C2h2-type zinc-finger]]
[[Category: Gc-box promoter element]]
[[Category: Kruppel-like factor]]
[[Category: Metal bind]]
[[Category: National project on protein structural and functional analyse]]
[[Category: Nppsfa]]
[[Category: Rsgi]]
[[Category: Transcription]]
[[Category: Transcription factor]]

Latest revision as of 21:48, 29 May 2024

Solution structure of three tandem repeats of zf-C2H2 domains from human Kruppel-like factor 5Solution structure of three tandem repeats of zf-C2H2 domains from human Kruppel-like factor 5

Structural highlights

2ebt is a 1 chain structure with sequence from Homo sapiens. The April 2009 RCSB PDB Molecule of the Month feature on Oct and Sox Transcription Factors by David Goodsell is 10.2210/rcsb_pdb/mom_2009_4. Full experimental information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:Solution NMR
Ligands:
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT, TOPSAN

Function

KLF5_HUMAN Transcription factor that binds to GC box promoter elements. Activates the transcription of these genes.

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

Drag the structure with the mouse to rotate

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OCA
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