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[[Image:2ebt.jpg|left|200px]]


{{Structure
==Solution structure of three tandem repeats of zf-C2H2 domains from human Kruppel-like factor 5==
|PDB= 2ebt |SIZE=350|CAPTION= <scene name='initialview01'>2ebt</scene>
<StructureSection load='2ebt' size='340' side='right'caption='[[2ebt]]' scene=''>
|SITE= <scene name='pdbsite=AC1:Zn+Binding+Site+For+Residue+A+100'>AC1</scene>, <scene name='pdbsite=AC2:Zn+Binding+Site+For+Residue+A+200'>AC2</scene> and <scene name='pdbsite=AC3:Zn+Binding+Site+For+Residue+A+300'>AC3</scene>
== Structural highlights ==
|LIGAND= <scene name='pdbligand=ZN:ZINC ION'>ZN</scene>
<table><tr><td colspan='2'>[[2ebt]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. The April 2009 RCSB PDB [https://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/index.html Molecule of the Month] feature on ''Oct and Sox Transcription Factors''  by David Goodsell is [https://dx.doi.org/10.2210/rcsb_pdb/mom_2009_4 10.2210/rcsb_pdb/mom_2009_4]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2EBT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2EBT FirstGlance]. <br>
|ACTIVITY=  
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
|GENE=  
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
}}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ebt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ebt OCA], [https://pdbe.org/2ebt PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ebt RCSB], [https://www.ebi.ac.uk/pdbsum/2ebt PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ebt ProSAT], [https://www.topsan.org/Proteins/RSGI/2ebt TOPSAN]</span></td></tr>
 
</table>
'''Solution structure of three tandem repeats of zf-C2H2 domains from human Kruppel-like factor 5'''
== Function ==
 
[https://www.uniprot.org/uniprot/KLF5_HUMAN KLF5_HUMAN] Transcription factor that binds to GC box promoter elements. Activates the transcription of these genes.
 
== Evolutionary Conservation ==
==About this Structure==
[[Image:Consurf_key_small.gif|200px|right]]
2EBT is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2EBT OCA].  
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/eb/2ebt_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2ebt ConSurf].
<div style="clear:both"></div>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Single protein]]
[[Category: Large Structures]]
[[Category: Hayashi, F.]]
[[Category: Oct and Sox Transcription Factors]]
[[Category: Nagashima, T.]]
[[Category: RCSB PDB Molecule of the Month]]
[[Category: RSGI, RIKEN Structural Genomics/Proteomics Initiative.]]
[[Category: Hayashi F]]
[[Category: Yokoyama, S.]]
[[Category: Nagashima T]]
[[Category: ZN]]
[[Category: Yokoyama S]]
[[Category: c2h2-type zinc-finger]]
[[Category: gc-box promoter element]]
[[Category: kruppel-like factor]]
[[Category: metal bind]]
[[Category: national project on protein structural and functional analyse]]
[[Category: nppsfa]]
[[Category: riken structural genomics/proteomics initiative]]
[[Category: rsgi]]
[[Category: structural genomic]]
[[Category: transcription factor]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 16:37:59 2008''

Latest revision as of 21:48, 29 May 2024

Solution structure of three tandem repeats of zf-C2H2 domains from human Kruppel-like factor 5Solution structure of three tandem repeats of zf-C2H2 domains from human Kruppel-like factor 5

Structural highlights

2ebt is a 1 chain structure with sequence from Homo sapiens. The April 2009 RCSB PDB Molecule of the Month feature on Oct and Sox Transcription Factors by David Goodsell is 10.2210/rcsb_pdb/mom_2009_4. Full experimental information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:Solution NMR
Ligands:
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT, TOPSAN

Function

KLF5_HUMAN Transcription factor that binds to GC box promoter elements. Activates the transcription of these genes.

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

Drag the structure with the mouse to rotate

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OCA
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