2e9h: Difference between revisions

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-[[Image:2e9h.png|left|200px]]
-{{STRUCTURE_2e9h|  PDB=2e9h  |  SCENE=  }}
+==Solution structure of the eIF-5_eIF-2B domain from human Eukaryotic translation initiation factor 5==
+<StructureSection load='2e9h' size='340' side='right'caption='[[2e9h]]' scene=''>
-===Solution structure of the eIF-5_eIF-2B domain from human Eukaryotic translation initiation factor 5===
+== Structural highlights ==
+<table><tr><td colspan='2'>[[2e9h]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2E9H OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2E9H FirstGlance]. <br>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
-==About this Structure==
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-[[2e9h]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2E9H OCA].
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2e9h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2e9h OCA], [https://pdbe.org/2e9h PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2e9h RCSB], [https://www.ebi.ac.uk/pdbsum/2e9h PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2e9h ProSAT], [https://www.topsan.org/Proteins/RSGI/2e9h TOPSAN]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/IF5_HUMAN IF5_HUMAN] Catalyzes the hydrolysis of GTP bound to the 40S ribosomal initiation complex (40S.mRNA.Met-tRNA[F].eIF-2.GTP) with the subsequent joining of a 60S ribosomal subunit resulting in the release of eIF-2 and the guanine nucleotide. The subsequent joining of a 60S ribosomal subunit results in the formation of a functional 80S initiation complex (80S.mRNA.Met-tRNA[F]).
+== Evolutionary Conservation ==
+[[Image:Consurf_key_small.gif|200px|right]]
+Check<jmol>
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/e9/2e9h_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2e9h ConSurf].
+<div style="clear:both"></div>
 ==See Also==
-*[[Eukaryotic initiation factor|Eukaryotic initiation factor]]
+*[[Eukaryotic initiation factor 3D structures|Eukaryotic initiation factor 3D structures]]
+__TOC__
+</StructureSection>
 [[Category: Homo sapiens]]
-[[Category: Harada, T.]]
+[[Category: Large Structures]]
-[[Category: Kigawa, T.]]
+[[Category: Harada T]]
-[[Category: Koshiba, S.]]
+[[Category: Kigawa T]]
-[[Category: RSGI, RIKEN Structural Genomics/Proteomics Initiative.]]
+[[Category: Koshiba S]]
-[[Category: Tochio, N.]]
+[[Category: Tochio N]]
-[[Category: Tomizawa, T.]]
+[[Category: Tomizawa T]]
-[[Category: Watanabe, S.]]
+[[Category: Watanabe S]]
-[[Category: Yokoyama, S.]]
+[[Category: Yokoyama S]]
-[[Category: C4 type zinc finger]]
-[[Category: National project on protein structural and functional analyse]]
-[[Category: Nppsfa]]
-[[Category: Riken structural genomics/proteomics initiative]]
-[[Category: Rsgi]]
-[[Category: Structural genomic]]
-[[Category: Translation]]
-[[Category: Translation initiation factor]]
-[[Category: Zinc binding]]