2e8m: Difference between revisions
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==Solution structure of the C-terminal SAM-domain of epidermal growth receptor pathway substrate 8== | |||
<StructureSection load='2e8m' size='340' side='right'caption='[[2e8m]]' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[2e8m]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2E8M OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2E8M FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2e8m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2e8m OCA], [https://pdbe.org/2e8m PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2e8m RCSB], [https://www.ebi.ac.uk/pdbsum/2e8m PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2e8m ProSAT], [https://www.topsan.org/Proteins/RSGI/2e8m TOPSAN]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/EPS8_HUMAN EPS8_HUMAN] Upon binding to EGF receptor/EGFR enhances EGF-dependent mitogenic signals. Can bind multiple cellular targets. | |||
== Evolutionary Conservation == | |||
[[Image:Consurf_key_small.gif|200px|right]] | |||
Check<jmol> | |||
<jmolCheckbox> | |||
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/e8/2e8m_consurf.spt"</scriptWhenChecked> | |||
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | |||
<text>to colour the structure by Evolutionary Conservation</text> | |||
</jmolCheckbox> | |||
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2e8m ConSurf]. | |||
<div style="clear:both"></div> | |||
== | ==See Also== | ||
*[[Epidermal growth factor receptor substrate 3D structures|Epidermal growth factor receptor substrate 3D structures]] | |||
__TOC__ | |||
</StructureSection> | |||
[[ | |||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Goroncy | [[Category: Large Structures]] | ||
[[Category: Inoue | [[Category: Goroncy AK]] | ||
[[Category: Kigawa | [[Category: Inoue M]] | ||
[[Category: Koshiba | [[Category: Kigawa T]] | ||
[[Category: Koshiba S]] | |||
[[Category: Sato | [[Category: Sato M]] | ||
[[Category: Yokoyama | [[Category: Yokoyama S]] | ||
Latest revision as of 21:48, 29 May 2024
Solution structure of the C-terminal SAM-domain of epidermal growth receptor pathway substrate 8Solution structure of the C-terminal SAM-domain of epidermal growth receptor pathway substrate 8
Structural highlights
FunctionEPS8_HUMAN Upon binding to EGF receptor/EGFR enhances EGF-dependent mitogenic signals. Can bind multiple cellular targets. Evolutionary Conservation Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf. See Also |
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