2e7h: Difference between revisions

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-[[Image:2e7h.jpg|left|200px]]
-<!--
+==Solution structure of the second fn3 domain from human Ephrin type-B receptor 4==
-The line below this paragraph, containing "STRUCTURE_2e7h", creates the "Structure Box" on the page.
+<StructureSection load='2e7h' size='340' side='right'caption='[[2e7h]]' scene=''>
-You may change the PDB parameter (which sets the PDB file loaded into the applet)
+== Structural highlights ==
-or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+<table><tr><td colspan='2'>[[2e7h]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2E7H OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2E7H FirstGlance]. <br>
-or leave the SCENE parameter empty for the default display.
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
--->
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2e7h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2e7h OCA], [https://pdbe.org/2e7h PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2e7h RCSB], [https://www.ebi.ac.uk/pdbsum/2e7h PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2e7h ProSAT], [https://www.topsan.org/Proteins/RSGI/2e7h TOPSAN]</span></td></tr>
-{{STRUCTURE_2e7h|  PDB=2e7h  |  SCENE=  }}
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/EPHB4_HUMAN EPHB4_HUMAN] Receptor tyrosine kinase which binds promiscuously transmembrane ephrin-B family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Together with its cognate ligand/functional ligand EFNB2 plays a central role in heart morphogenesis and angiogenesis through regulation of cell adhesion and cell migration. EPHB4-mediated forward signaling controls cellular repulsion and segregation form EFNB2-expressing cells. Plays also a role in postnatal blood vessel remodeling, morphogenesis and permeability and is thus important in the context of tumor angiogenesis.<ref>PMID:12734395</ref> <ref>PMID:16424904</ref>
+== Evolutionary Conservation ==
+[[Image:Consurf_key_small.gif|200px|right]]
+Check<jmol>
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/e7/2e7h_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2e7h ConSurf].
+<div style="clear:both"></div>
-'''Solution structure of the second fn3 domain from human Ephrin type-B receptor 4'''
+==See Also==
+*[[Ephrin receptor 3D structures|Ephrin receptor 3D structures]]
+== References ==
-==About this Structure==
+<references/>
-E7H is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2E7H OCA].
+__TOC__
+</StructureSection>
 [[Category: Homo sapiens]]
-[[Category: Receptor protein-tyrosine kinase]]
+[[Category: Large Structures]]
-[[Category: Single protein]]
+[[Category: Hayashi F]]
-[[Category: Hayashi, F.]]
+[[Category: Qin XR]]
-[[Category: Qin, X R.]]
+[[Category: Yokoyama S]]
-[[Category: RSGI, RIKEN Structural Genomics/Proteomics Initiative.]]
-[[Category: Yokoyama, S.]]
-[[Category: Ephrin type-b receptor 4 precursor]]
-[[Category: Fn3 domain]]
-[[Category: National project on protein structural and functional analyse]]
-[[Category: Nppsfa]]
-[[Category: Riken structural genomics/proteomics initiative]]
-[[Category: Rsgi]]
-[[Category: Structural genomic]]
-[[Category: Tyrosine-protein kinase receptor htk]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May  4 02:04:30 2008''