2e6p: Difference between revisions

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-[[Image:2e6p.png|left|200px]]
-{{STRUCTURE_2e6p|  PDB=2e6p  |  SCENE=  }}
+==Solution structure of the Ig-like domain (714-804) from human Obscurin-like protein 1==
+<StructureSection load='2e6p' size='340' side='right'caption='[[2e6p]]' scene=''>
-===Solution structure of the Ig-like domain (714-804) from human Obscurin-like protein 1===
+== Structural highlights ==
+<table><tr><td colspan='2'>[[2e6p]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2E6P OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2E6P FirstGlance]. <br>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
-==About this Structure==
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2e6p FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2e6p OCA], [https://pdbe.org/2e6p PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2e6p RCSB], [https://www.ebi.ac.uk/pdbsum/2e6p PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2e6p ProSAT], [https://www.topsan.org/Proteins/RSGI/2e6p TOPSAN]</span></td></tr>
-[[2e6p]] is a 1 chain structure of [[Obscurin]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2E6P OCA].
+</table>
+== Disease ==
+[https://www.uniprot.org/uniprot/OBSL1_HUMAN OBSL1_HUMAN] Defects in OBSL1 are the cause of 3M syndrome type 2 (3M2) [MIM:[https://omim.org/entry/612921 612921]. An autosomal recessive disorder characterized by severe pre- and postnatal growth retardation, facial dysmorphism, large head circumference, and normal intelligence and endocrine function. Skeletal changes include long slender tubular bones and tall vertebral bodies.<ref>PMID:19481195</ref>
+== Function ==
+[https://www.uniprot.org/uniprot/OBSL1_HUMAN OBSL1_HUMAN]
+== Evolutionary Conservation ==
+[[Image:Consurf_key_small.gif|200px|right]]
+Check<jmol>
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/e6/2e6p_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2e6p ConSurf].
+<div style="clear:both"></div>
 ==See Also==
 *[[Obscurin|Obscurin]]
+== References ==
+<references/>
+__TOC__
+</StructureSection>
 [[Category: Homo sapiens]]
-[[Category: Hayashi, F.]]
+[[Category: Large Structures]]
-[[Category: Qin, X R.]]
+[[Category: Hayashi F]]
-[[Category: RSGI, RIKEN Structural Genomics/Proteomics Initiative.]]
+[[Category: Qin XR]]
-[[Category: Suetake, T.]]
+[[Category: Suetake T]]
-[[Category: Yokoyama, S.]]
+[[Category: Yokoyama S]]
-[[Category: Ig-like domain]]
-[[Category: National project on protein structural and functional analyse]]
-[[Category: Nppsfa]]
-[[Category: Obscurin-like protein 1]]
-[[Category: Riken structural genomics/proteomics initiative]]
-[[Category: Rsgi]]
-[[Category: Structural genomic]]
-[[Category: Structural protein]]