2dmh: Difference between revisions

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==Solution structure of the first C2 domain of human myoferlin==
==Solution structure of the first C2 domain of human myoferlin==
<StructureSection load='2dmh' size='340' side='right' caption='[[2dmh]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
<StructureSection load='2dmh' size='340' side='right'caption='[[2dmh]]' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[2dmh]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DMH OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2DMH FirstGlance]. <br>
<table><tr><td colspan='2'>[[2dmh]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DMH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2DMH FirstGlance]. <br>
</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">FER1L3, KIAA1207, MYOF ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2dmh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2dmh OCA], [http://pdbe.org/2dmh PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2dmh RCSB], [http://www.ebi.ac.uk/pdbsum/2dmh PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2dmh ProSAT], [http://www.topsan.org/Proteins/RSGI/2dmh TOPSAN]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2dmh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2dmh OCA], [https://pdbe.org/2dmh PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2dmh RCSB], [https://www.ebi.ac.uk/pdbsum/2dmh PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2dmh ProSAT], [https://www.topsan.org/Proteins/RSGI/2dmh TOPSAN]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/MYOF_HUMAN MYOF_HUMAN]] Calcium/phospholipid-binding protein that plays a role in the plasmalemma repair mechanism of endothelial cells that permits rapid resealing of membranes disrupted by mechanical stress. Involved in endocytic recycling. Implicated in VEGF signal transduction by regulating the levels of the receptor KDR (By similarity).  
[https://www.uniprot.org/uniprot/MYOF_HUMAN MYOF_HUMAN] Calcium/phospholipid-binding protein that plays a role in the plasmalemma repair mechanism of endothelial cells that permits rapid resealing of membranes disrupted by mechanical stress. Involved in endocytic recycling. Implicated in VEGF signal transduction by regulating the levels of the receptor KDR (By similarity).
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Human]]
[[Category: Homo sapiens]]
[[Category: Hayashi, F]]
[[Category: Large Structures]]
[[Category: Nagashima, T]]
[[Category: Hayashi F]]
[[Category: Structural genomic]]
[[Category: Nagashima T]]
[[Category: Yokoyama, S]]
[[Category: Yokoyama S]]
[[Category: Beta-sandwich]]
[[Category: Cardiomyopathy]]
[[Category: Dystrophin]]
[[Category: Fer-1-like protein 3]]
[[Category: Lipid binding protein]]
[[Category: Membrane fusion]]
[[Category: Muscular dystrophy]]
[[Category: National project on protein structural and functional analyse]]
[[Category: Nppsfa]]
[[Category: Rsgi]]

Latest revision as of 21:44, 29 May 2024

Solution structure of the first C2 domain of human myoferlinSolution structure of the first C2 domain of human myoferlin

Structural highlights

2dmh is a 1 chain structure with sequence from Homo sapiens. Full experimental information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:Solution NMR
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT, TOPSAN

Function

MYOF_HUMAN Calcium/phospholipid-binding protein that plays a role in the plasmalemma repair mechanism of endothelial cells that permits rapid resealing of membranes disrupted by mechanical stress. Involved in endocytic recycling. Implicated in VEGF signal transduction by regulating the levels of the receptor KDR (By similarity).

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

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OCA
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