2dl8: Difference between revisions

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-[[Image:2dl8.gif|left|200px]]
-<!--
+==Solution structure of the SH3 domain of human SLIT-ROBO Rho GTPase-activating protein 2==
-The line below this paragraph, containing "STRUCTURE_2dl8", creates the "Structure Box" on the page.
+<StructureSection load='2dl8' size='340' side='right'caption='[[2dl8]]' scene=''>
-You may change the PDB parameter (which sets the PDB file loaded into the applet)
+== Structural highlights ==
-or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+<table><tr><td colspan='2'>[[2dl8]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DL8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2DL8 FirstGlance]. <br>
-or leave the SCENE parameter empty for the default display.
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
--->
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2dl8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2dl8 OCA], [https://pdbe.org/2dl8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2dl8 RCSB], [https://www.ebi.ac.uk/pdbsum/2dl8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2dl8 ProSAT], [https://www.topsan.org/Proteins/RSGI/2dl8 TOPSAN]</span></td></tr>
-{{STRUCTURE_2dl8|  PDB=2dl8  |  SCENE=  }}
+</table>
+== Disease ==
+[https://www.uniprot.org/uniprot/SRGP2_HUMAN SRGP2_HUMAN] A chromosomal aberration disrupting SRGAP2 has been found in a patient with early infantile epileptic encephalopathy. Balanced translocation t(1;9)(q32;q13).
+== Function ==
+[https://www.uniprot.org/uniprot/SRGP2_HUMAN SRGP2_HUMAN] RAC1 GTPase activating protein (GAP) that binds and deforms membranes, and regulates actin dynamics to regulate cell migration and differentiation. Plays an important role in different aspects of neuronal morphogenesis and migration mainly during development of the cerebral cortex. This includes the biogenesis of neurites, where it is required for both axons and dendrites outgrowth, and the maturation of the dendritic spines. Also stimulates the branching of the leading process and negatively regulates neuron radial migration in the cerebral cortex. Its interaction and inhibition by SRGAP2C reduces the rate of spine maturation, alters dendritic spine morphology and density and indirectly increases neuronal migration. It may have implications for cognition, learning and memory. In non-neuronal cells, it may also play a role in cell migration by regulating the formation of lamellipodia and filopodia.<ref>PMID:20810653</ref> <ref>PMID:21148482</ref> <ref>PMID:22559944</ref>
+== Evolutionary Conservation ==
+[[Image:Consurf_key_small.gif|200px|right]]
+Check<jmol>
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/dl/2dl8_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2dl8 ConSurf].
+<div style="clear:both"></div>
-'''Solution structure of the SH3 domain of human SLIT-ROBO Rho GTPase-activating protein 2'''
+==See Also==
+*[[Rho GTPase activating protein 3D structures|Rho GTPase activating protein 3D structures]]
+== References ==
-==About this Structure==
+<references/>
-DL8 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DL8 OCA].
+__TOC__
+</StructureSection>
 [[Category: Homo sapiens]]
-[[Category: Single protein]]
+[[Category: Large Structures]]
-[[Category: Hayashi, F.]]
+[[Category: Hayashi F]]
-[[Category: Qin, X R.]]
+[[Category: Qin XR]]
-[[Category: RSGI, RIKEN Structural Genomics/Proteomics Initiative.]]
+[[Category: Yokoyama S]]
-[[Category: Yokoyama, S.]]
-[[Category: Formin-binding protein 2]]
-[[Category: National project on protein structural and functional analyse]]
-[[Category: Nppsfa]]
-[[Category: Riken structural genomics/proteomics initiative]]
-[[Category: Rsgi]]
-[[Category: Sh3 domain]]
-[[Category: Slit-robo rho gtpase activating protein 2]]
-[[Category: Structural genomic]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May  4 00:39:55 2008''