1rsv: Difference between revisions

No edit summary
No edit summary
 
(3 intermediate revisions by the same user not shown)
Line 1: Line 1:


==azide complex of the diferrous E238A mutant R2 subunit of ribonucleotide reductase==
==azide complex of the diferrous E238A mutant R2 subunit of ribonucleotide reductase==
<StructureSection load='1rsv' size='340' side='right' caption='[[1rsv]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
<StructureSection load='1rsv' size='340' side='right'caption='[[1rsv]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[1rsv]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_coli"_migula_1895 "bacillus coli" migula 1895]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1RSV OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1RSV FirstGlance]. <br>
<table><tr><td colspan='2'>[[1rsv]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1RSV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1RSV FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=AZI:AZIDE+ION'>AZI</scene>, <scene name='pdbligand=FE:FE+(III)+ION'>FE</scene>, <scene name='pdbligand=HG:MERCURY+(II)+ION'>HG</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2&#8491;</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1rsr|1rsr]], [[1mxr|1mxr]], [[1xik|1xik]]</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=AZI:AZIDE+ION'>AZI</scene>, <scene name='pdbligand=FE:FE+(III)+ION'>FE</scene>, <scene name='pdbligand=HG:MERCURY+(II)+ION'>HG</scene></td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Ribonucleoside-diphosphate_reductase Ribonucleoside-diphosphate reductase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.17.4.1 1.17.4.1] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1rsv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1rsv OCA], [https://pdbe.org/1rsv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1rsv RCSB], [https://www.ebi.ac.uk/pdbsum/1rsv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1rsv ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1rsv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1rsv OCA], [http://pdbe.org/1rsv PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1rsv RCSB], [http://www.ebi.ac.uk/pdbsum/1rsv PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1rsv ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/RIR2_ECOLI RIR2_ECOLI]] Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. R2 contains the tyrosyl radical required for catalysis.  
[https://www.uniprot.org/uniprot/RIR2_ECOLI RIR2_ECOLI] Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. R2 contains the tyrosyl radical required for catalysis.
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Line 32: Line 31:


==See Also==
==See Also==
*[[Ribonucleotide reductase|Ribonucleotide reductase]]
*[[Ribonucleotide reductase 3D structures|Ribonucleotide reductase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Bacillus coli migula 1895]]
[[Category: Escherichia coli]]
[[Category: Ribonucleoside-diphosphate reductase]]
[[Category: Large Structures]]
[[Category: Andersson, M E]]
[[Category: Andersson ME]]
[[Category: Assarsson, M]]
[[Category: Assarsson M]]
[[Category: Barra, A L]]
[[Category: Barra AL]]
[[Category: Graslund, A]]
[[Category: Graslund A]]
[[Category: Hogbom, M]]
[[Category: Hogbom M]]
[[Category: Nordlund, P]]
[[Category: Nordlund P]]
[[Category: Persson, B O]]
[[Category: Persson BO]]
[[Category: Sahlin, M]]
[[Category: Sahlin M]]
[[Category: Sjoberg, B M]]
[[Category: Sjoberg BM]]
[[Category: Azide]]
[[Category: Chemical rescue]]
[[Category: Diiron]]
[[Category: Oxidoreductase]]
[[Category: Radical generation]]

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA