1pc2: Difference between revisions

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==Solution structure of human mitochondria fission protein Fis1==
==Solution structure of human mitochondria fission protein Fis1==
<StructureSection load='1pc2' size='340' side='right' caption='[[1pc2]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
<StructureSection load='1pc2' size='340' side='right'caption='[[1pc2]]' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[1pc2]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PC2 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1PC2 FirstGlance]. <br>
<table><tr><td colspan='2'>[[1pc2]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PC2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1PC2 FirstGlance]. <br>
</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Fis1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1pc2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1pc2 OCA], [http://pdbe.org/1pc2 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1pc2 RCSB], [http://www.ebi.ac.uk/pdbsum/1pc2 PDBsum]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1pc2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1pc2 OCA], [https://pdbe.org/1pc2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1pc2 RCSB], [https://www.ebi.ac.uk/pdbsum/1pc2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1pc2 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/FIS1_HUMAN FIS1_HUMAN]] Promotes the fragmentation of the mitochondrial network and its perinuclear clustering. Can induce cytochrome c release from the mitochondrion to the cytosol, ultimately leading to apoptosis. Also mediates peroxisomal fission.<ref>PMID:12783892</ref> <ref>PMID:12861026</ref> <ref>PMID:14996942</ref> <ref>PMID:16118244</ref> <ref>PMID:16107562</ref>
[https://www.uniprot.org/uniprot/FIS1_HUMAN FIS1_HUMAN] Promotes the fragmentation of the mitochondrial network and its perinuclear clustering. Can induce cytochrome c release from the mitochondrion to the cytosol, ultimately leading to apoptosis. Also mediates peroxisomal fission.<ref>PMID:12783892</ref> <ref>PMID:12861026</ref> <ref>PMID:14996942</ref> <ref>PMID:16118244</ref> <ref>PMID:16107562</ref>  
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
Check<jmol>
   <jmolCheckbox>
   <jmolCheckbox>
     <scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/pc/1pc2_consurf.spt"</scriptWhenChecked>
     <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/pc/1pc2_consurf.spt"</scriptWhenChecked>
     <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
     <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
     <text>to colour the structure by Evolutionary Conservation</text>
     <text>to colour the structure by Evolutionary Conservation</text>
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Human]]
[[Category: Homo sapiens]]
[[Category: Suzuki, M]]
[[Category: Large Structures]]
[[Category: Tjandra, N]]
[[Category: Suzuki M]]
[[Category: Youle, R J]]
[[Category: Tjandra N]]
[[Category: Fission]]
[[Category: Youle RJ]]
[[Category: Mitochondria]]
[[Category: Unknown function]]

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