Anthrax protective antigen: Difference between revisions
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== Function == | == Function == | ||
'''Anthrax protective antigen''' (PA) is the cell-binding part of the ''Bacillus anthracis'' anthrax toxin. The anthrax toxin is composed of the PA, lethal factor and edema factor. | '''Anthrax protective antigen''' (PA) is the cell-binding part of the ''Bacillus anthracis'' anthrax toxin. The anthrax toxin is composed of the PA, lethal factor and edema factor. The PA translocates the [[Anthrax Lethal Factor|lethal]] (LF) and [[Anthrax edema factor|edema]] factors (EF) into the cell. The 83kD form of PA '''(PA83)''' binds to the anthrax toxin receptor. A 20kD fragment (PA20) is cleaved off the PA83 and the remaining '''PA63''' assembles into ring-shaped oligomer which becomes a membrane pre-channel. The PA pre-channel binds the lethal and edema factors allowing them to penetrate the membrane via pH gradient. | ||
For more details see | |||
*[[Molecular Playground/Protective Antigen]]<br /> | |||
*[[Anthrax Toxin Protein]]<br /> | |||
*[[Toxins]]. | |||
== Structural highlights == | == Structural highlights == | ||