Annexin: Difference between revisions

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Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

Alexander Berchansky, Michal Harel, Jaime Prilusky

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-[[Image:1ain.png|left|200px|thumb|Crystal Structure of Human Annexin I, [[1ain]]]]
+<StructureSection load='1n42' size='350' side='right' caption='Rat annexin V complex with Ca+2 (green) and sulfate (PDB code [[1n42]])' scene='41/410357/Cv/3'>
-{{STRUCTURE_1ain|  PDB=1ain  | SIZE=300| SCENE=Annexin/Cv/2 |right|CAPTION=Human Annexin I, [[1ain]] }}
+__TOC__
+== Function ==
-[[Annexin|Annexins]] are proteins which make a membrane scaffold. They bind negatively charged phospholipids and contain a 70 amino acid long annexin repeat. They consist of 2 domains - the C-terminal core and the N-terminal head. Annexins divide into species and are numbered from I to XII. Annexin V is the most abundant scaffolding protein. In the annexin image calcium ions are shown as green balls.
+[[Annexin|Annexins]] are proteins which make a membrane scaffold. They bind negatively charged phospholipids and contain a 70 amino acid long annexin repeat.  Annexins divide into species and are numbered from I to XII.
+*'''Annexin I''' is involved in a variety of pathways<ref>PMID:17215481</ref>. <br />
+*'''Annexin II''' is involved in angiogenesis, tutor progression and metastasis<ref>PMID:18220793</ref>. See also [[Ezetimibe]].<br /><br />
+*'''Annexin V''' is the most abundant scaffolding protein. <br />
+*'''Annexin VI''' is involved in endocytosis and regulates entry of ligands to prelysosomal compartment<ref>PMID:10940299</ref>. <br />
+*'''Annexin VIII''' is calcium-dependent phospholipid-binding involved in blood coagulation<ref>PMID:8018923</ref>. <br />
+*'''Annexin E1''' (AnE1) is associated with tubulin in trophozoites of ''Giardia lamblia'' and forms local slubs in the flagella. <br />
+*'''Annexin A-V''' has a major role in coagulation.  <br />
-== Annexin I ==
+== Relevance ==
+Annexin I is involved in anti-inflammatory responses and apoptotic mechanisms.
-[[2q4c]], [[1ycn]] - AnI - ''Arabidopsis thaliana''<br />
+== Structural highlights ==
-[[1mcx]], [[1hm6]] - pAnI - pig<br />
-[[1qls]] - pAnI head+calgizzarrin<br />
-[[1bo9]] - hAnI head - human NMR<br />
-[[1ain]] - hAnI<br />
+Annexins consist of 2 domains - the C-terminal core and the N-terminal head. The <scene name='41/410357/Cv/9'>core domain consists of 4 annexin repeats</scene> containing <scene name='41/410357/Cv/10'>5 helices</scene>. The core domain concave side contains the <scene name='41/410357/Cv/11'>Ca+2 binding sites</scene>.<ref>PMID:12401794</ref>
-== Annexin II ==
+==3D structures of annexin==
+[[Annexin 3D structures]]
+</StructureSection>
-[[2hyu]], [[2hyv]] - hAnII+heparin oligosaccharide<br />
-[[2hyw]], [[1xjl]] - hAnII+Ca<br />
-[[1w7b]] - hAnII<br />
-[[1bt6]] - hAnII head+calpactin light chain<br />
-== Annexin III ==
-[[1aii]], [[1axn]] - hAnIII<br />
-== Annexin IV ==
-[[2zhi]], [[2zhj]], rAnIV+Na - rat<br />
-[[2zoc]] - hAnIV<br />
-[[1i4a]] - cAnIV (mutant) - cow<br />
-[[1aow]], [[1ann]] - cAnIV<br />
-== Annexin V ==
-[[2ie6]], [[2ie7]], rAnV<br />
-[[1n41]], [[1n42]], [[1n44]], [[2h0k]], [[2h0l]], [[2h0m]], [[1bc0]], [[1bc1]], [[1bc3]], [[1bcw]], [[1bcy]], [[1bcz]]  - rAnV (mutant)<br />
-[[1g5n]] - rAnV+ heparin oligosaccharide<br />
-[[1a8a]], [[1a8b]] - rAnV+phospholipid analog<br />
-[[2ran]] - rAnV+Ca<br />
-[[1yii]] – chAnV+Ca – chicken<br />
-[[1yj0]] - chAnV+Zn<br />
-[[1ala]] - ChAnV<br />
-[[1hak]] - hAnV+K-201<br />
-[[1sav]] - hAnV (thioproline)<br />
-[[1hvd]], [[1hve]], [[1hvf]], [[1hvg]] - hAnV (mutant)<br />
-[[1anw]], [[1avh]], [[1avr]] - hAnV<br />
-[[1anx]] - hAnV+Ca<br />
-== Annexin VI ==
-[[1m9i]] - hAnVI (mutant)<br />
-[[1avc]] - cAnVI+Ca<br />
-== Annexin VIII ==
-[[1w3w]] - hAnVIII<br />
-[[1w45]] - hAnVIII (mutant)<br />
-== Annexin XII ==
-[[1dm5]] - HvAnXII (mutant) - ''Hydra vulgaris''<br />
-[[1aei]] - HvAnXII<br />
-== Other annexins ==
-[[1dk5]] - An24 - ''Capsicom annuum''<br />
-[[3brx]] - coAnGH1+Ca - cotton<br />
-[[1n00]] - coAnGH1<br />
+== References ==
+<references/>
 [[Category:Topic Page]]