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Ankyrin repeat domain-containing protein: Difference between revisions

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== Disease ==
== Disease ==


Mutations in ARDCP 3 manifest as Bartsocas-Papas syndrome, a genetic disorder characterized by severe craniofacial and limb abnormalities<ref>PMID:29706531</ref>.
Mutations in '''ARDCP 3''' manifest as Bartsocas-Papas syndrome, a genetic disorder characterized by severe craniofacial and limb abnormalities<ref>PMID:29706531</ref>.


== Structural highlights ==
== Structural highlights ==


The 3D structure of the complex between human ARDCP 25 C-terminal and a kinesin peptide shows 2 types of interactions.  Kinesin residues <scene name='86/863150/Cv/3'>KARR interact in an acidic pocket</scene> and residues <scene name='86/863150/Cv/6'>QMELLYA interact in a hydrophobic pocket</scene><ref name="Guo"/>. <scene name='86/863150/Cv/5'>Whole kinesin peptide binding site</scene>.  
The 3D structure of the complex between human ARDCP 25 C-terminal and a kinesin peptide shows 2 types of interactions.  Kinesin residues <scene name='86/863150/Cv/3'>KARR interact in an acidic pocket</scene> and residues <scene name='86/863150/Cv/6'>QMELLYA interact in a hydrophobic pocket</scene><ref name="Guo"/>. <scene name='86/863150/Cv/5'>Whole kinesin peptide binding site</scene>.  
== 3D structures of ankyrin repeat domain-containing protein ==
[[Ankyrin repeat domain-containing protein 3D structures]]


</StructureSection>
</StructureSection>


== 3D structures of ankyrin repeat domain-containing protein ==
[[4nl9]] - hARDCP 3 SAM domain + hARDCP 14 SAM domain - human<br />
[[5ybj]] - hARDCP 15 residues 1080-1329<br />
[[5ybu]] - hARDCP 15 residues 1080-1329 + KIF21A peptide<br />
[[4hbd]] - hARDCP 25 residues 578-832<br />
[[6tmd]] - hARDCP 25 residues 583-832 (mutant)<br />
[[5ybv]] - hARDCP 25 residues 578-832 + KIF21A peptide<br />
[[4cym]] - hARDCP 27 residues 450-640 + RAB32<br />
[[4cz2]] - hARDCP 27 residues 450-640 + RAB32 + GPPCP<br />
[[4b93]] - hARDCP 27 residues 659-921 + VAMP7<br />
[[5wni]] - mARDCP 3 residues 1-342 - mouse<br />
[[5wnk]] - mARDCP 3 residues 1-342 (mutant)<br />
[[5wnj]], [[5wnm]] - mARDCP 3 residues 1-342 (mutant) + cancer drug<br />
[[5wnl]] - mARDCP 3 residues 1-342 (mutant) + staurosporine<br />
[[6nxf]] - mARDCP 31 C-terminal + REC114<br />
[[6tlh]] - mARDCP 47 residues 524-773 <br />
[[5eid]], [[4tum]] - AtARDCP 2 residues 211-342 - ''Arabidopis thaliana''<br />
[[6jd6]] - AtARDCP EMB56 + ARDCP<br />
== References ==
<references/>
<references/>
[[Category:Topic Page]]
[[Category:Topic Page]]

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Michal Harel, Joel L. Sussman, Alexander Berchansky
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