Ankyrin repeat domain-containing protein: Difference between revisions
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<StructureSection load='5ybv' size=' | <StructureSection load='5ybv' size='400' side='right' caption='Human ARDCP 25 (cyan and green) complex with kinesin peptide (pink and yellow), sulfate and glycerol (PDB code [[5ybv]]).' scene='86/863150/Cv/1'> | ||
== Function == | == Function == | ||
'''Ankyrin repeat domain-containing protein''' (ARDCP) recruits kinesin to the cell cortex in order to control microtubule growth via its ankyrin domain<ref>PMID:29183992</ref>. | '''Ankyrin repeat domain-containing protein''' (ARDCP) recruits kinesin to the cell cortex in order to control microtubule growth via its ankyrin domain<ref name="Guo">PMID:29183992</ref>. | ||
== Disease == | == Disease == | ||
Mutations in ARDCP 3 manifest as Bartsocas-Papas syndrome, a genetic disorder characterized by severe craniofacial and limb abnormalities<ref>PMID:29706531</ref>. | Mutations in '''ARDCP 3''' manifest as Bartsocas-Papas syndrome, a genetic disorder characterized by severe craniofacial and limb abnormalities<ref>PMID:29706531</ref>. | ||
== Structural highlights == | == Structural highlights == | ||
The 3D structure of the complex between human ARDCP 25 C-terminal and a kinesin peptide shows 2 types of interactions. Kinesin residues KARR interact in an acidic pocket and residues QMELLYA interact in a hydrophobic pocket<ref> | The 3D structure of the complex between human ARDCP 25 C-terminal and a kinesin peptide shows 2 types of interactions. Kinesin residues <scene name='86/863150/Cv/3'>KARR interact in an acidic pocket</scene> and residues <scene name='86/863150/Cv/6'>QMELLYA interact in a hydrophobic pocket</scene><ref name="Guo"/>. <scene name='86/863150/Cv/5'>Whole kinesin peptide binding site</scene>. | ||
== 3D structures of ankyrin repeat domain-containing protein == | |||
[[Ankyrin repeat domain-containing protein 3D structures]] | |||
</StructureSection> | </StructureSection> | ||
<references/> | <references/> | ||
[[Category:Topic Page]] | |||
Latest revision as of 12:31, 26 May 2024
FunctionAnkyrin repeat domain-containing protein (ARDCP) recruits kinesin to the cell cortex in order to control microtubule growth via its ankyrin domain[1]. DiseaseMutations in ARDCP 3 manifest as Bartsocas-Papas syndrome, a genetic disorder characterized by severe craniofacial and limb abnormalities[2]. Structural highlightsThe 3D structure of the complex between human ARDCP 25 C-terminal and a kinesin peptide shows 2 types of interactions. Kinesin residues and residues [1]. . 3D structures of ankyrin repeat domain-containing proteinAnkyrin repeat domain-containing protein 3D structures
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- ↑ 1.0 1.1 Guo Q, Liao S, Zhu Z, Li Y, Li F, Xu C. Structural basis for the recognition of kinesin family member 21A (KIF21A) by the ankyrin domains of KANK1 and KANK2 proteins. J Biol Chem. 2017 Nov 28. pii: M117.817494. doi: 10.1074/jbc.M117.817494. PMID:29183992 doi:http://dx.doi.org/10.1074/jbc.M117.817494
- ↑ Huang CS, Oberbeck N, Hsiao YC, Liu P, Johnson AR, Dixit VM, Hymowitz SG. Crystal Structure of Ripk4 Reveals Dimerization-Dependent Kinase Activity. Structure. 2018 May 1;26(5):767-777.e5. doi: 10.1016/j.str.2018.04.002. Epub 2018, Apr 26. PMID:29706531 doi:http://dx.doi.org/10.1016/j.str.2018.04.002