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| == Function == | | == Function == |
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| '''Alpha glucosidase''' (AGS) or '''maltase''' breaks down the 1,4-α bonds in starch or disaccharides to produce glucose. '''Maltase''' breaks down maltose. '''Isomaltase''' breaks the 1,6 bond.<ref>PMID:18848471</ref> See also [[Kennedy research]]. | | '''Alpha glucosidase''' (AGS) or '''maltase''' breaks down the 1,4-α bonds in starch or disaccharides to produce glucose. '''Maltase''' breaks down maltose. '''Isomaltase''' or '''sucrase-isomaltase''' or '''oligo-1,6-glucosidase''' breaks the 1,6 bond.<ref>PMID:18848471</ref> |
| | *'''Maltase-glucoamylase''' has important role in glucose production. It hydrolize linear alpha-1,4-linked oligosaccharides<ref>PMID:22058037</ref>.<br /> |
| | *'''Acid-alpha gucosidase''' degrades glycogen polymers to glucose in the acidic lysosomes<ref>PMID:17217857</ref>.<br /> |
| | *'''6-phospho-alpha gucosidase''' hydrolyses maltose-6"-phosphate<ref>PMID:15341727</ref>.<br /> |
| | *'''Glucan 1,4-alpha gucosidase''' hydrolyses the terminal 1,4-linked alpha-D-glucose residues in polysaccharides to produce beta-glucose.<br /> |
| | For details see [[Sucrase-isomaltase]]. |
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| | See also [[Kennedy research]] and [[Carbohydrate Metabolism]]. |
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| == Disease == | | == Disease == |
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| == Structural highlights == | | == Structural highlights == |
| <scene name='59/596427/Cv/2'>α-D-glucose binding site</scene> (PDB code [[3a4a]]).<ref>PMID:20812985</ref> | | <scene name='59/596427/Cv/3'>α-D-glucose binding site</scene> (PDB code [[3a4a]]).<ref>PMID:20812985</ref> Water molecules shown as red spheres. |
| | <scene name='59/596427/Cv/5'>Ca coordination site</scene>. |
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| | ==3D structures of α-glucosidase== |
| | [[Alpha-glucosidase 3D structures]] |
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| </StructureSection> | | </StructureSection> |
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| ==3D structures of α-glucosidase==
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| Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
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| {{#tree:id=OrganizedByTopic|openlevels=0|
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| *Alpha glucosidase
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| **[[2g3m]] – SsAGS – ''Sulfolobus solfataricus''<br />
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| **[[2ze0]] – AGS – ''Geobacillus''<br />
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| **[[3w38]] – bAGS - beet<br />
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| **[[2d73]], [[2jka]], [[3wfa]], [[5djw]], [[5f7c]], [[3wfa]], [[3a24]] – BtAGS – ''Bacterioides thetaiotaomicron''<br />
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| **[[5hq4]] – PaAGS - ''Pseudoalteromonas''<br />
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| **[[1lf6]] – TtAGS – ''Thermoanaerobobacterium thermosaccharolyticum''<br />
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| **[[1kum]], [[1kul]] – AnAGS starch-binding domain – ''Aspergillus niger'' - NMR<br />
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| **[[3eqa]] – AnAGS catalytic domain <br />
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| **[[1glm]], [[3gly]] – AaAGS – ''Aspergillus awamori''<br />
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| **[[1ayx]], [[2fba]] – SfAGS – ''Saccharomycopsis fibuligera''<br />
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| **[[5f0e]] – mAGS - mouse<br />
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| **[[5aed]], [[5aee]], [[5aeg]] – AGS - ''Esherichia coli''<br />
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| **[[3wy1]] – HaAGS - ''Halomonas''<br />
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| **[[4xpo]] – PsAGS - ''Pedobacter saltans''<br />
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| **[[4xpr]] – PsAGS (mutant)<br />
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| *Alpha-glucosidase complex
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| **[[2jke]] – BtAGS + deoxynojirimycin<br />
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| **[[2jkp]] – BtAGS + castasnospermine<br />
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| **[[2zq0]] – BtAGS + acarbose<br />
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| **[[5hqa]] – PaAGS + acarbose <br />
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| **[[5hqb]] – PaAGS (mutant) + panose <br />
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| **[[1lf9]] – TtAGS + acarbose<br />
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| **[[1gai]], [[1gah]], [[1agm]] – AaAGS + acarbose<br />
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| **[[2f6d]] – SfAGS + acarbose<br />
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| **[[1dog]] – AaAGS + deoxynojirimycin<br />
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| **[[1acz]], [[1ac0]] – AGS starch-binding domain + cyclodextrin - NMR<br />
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| **[[5hjr]] – AGS + glucosidase subunit beta - mouse<br />
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| **[[5h9o]] – mAGS + glucose<br />
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| **[[5hjo]] – mAGS + substrate analog<br />
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| **[[5h9r]] – mAGS + intermediate<br />
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| **[[5ied]], [[5iee]], [[5ief]], [[5ieg]] – mAGS + iminosugar antiviral<br />
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| **[[3wy2]] – HaAGS + glucose<br />
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| **[[3wy3]] – HaAGS (mutant) + glucose<br />
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| **[[3wy4]] – HaAGS (mutant) + maltose<br />
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| **[[4xpp]] – PsAGS + galactose<br />
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| **[[4xpq]] – PsAGS + fucose<br />
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| **[[4xps]] – PsAGS (mutant) + galactpiranoside<br />
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| **[[3wel]], [[3wem]], [[3wen]], [[3weo]], [[3w37]] – bAGS + substrate<br />
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| *Maltase complex
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| **[[1vjt]] – TmAGS + NAD – ''Thermotoga maritima''<br />
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| **[[1obb]] – TmAGS + NAD + maltose <br />
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| **[[2g3n]] – SsAGS + octylglucoside<br />
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| **[[3ton]] – hAGS C-terminal - human<br />
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| **[[3top]] – hAGS C-terminal + acarbose <br />
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| **[[3l4y]], [[3l4z]], [[3l4x]], [[3l4w]], [[3l4v]], [[3l4u]], [[3l4t]] – hAGS N-terminal + inhibitor<br />
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| *Isomaltase
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| **[[3a47]], [[3aj7]] – yAGS – yeast<br />
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| **[[3a4a]], [[3axh]] – yAGS + glucose<br />
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| **[[3axi]] – yAGS (mutant) + glucose<br />
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| **[[3n04]] – RoAGS – ''Ruminococcus obeum''<br />
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| **[[3nsx]], [[3nuk]] – RoAGS (mutant)<br />
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| **[[3pha]], [[3poc]] – RoAGS (mutant) + acarbose<br />
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| **[[3mkk]] – RoAGS + isomaltose <br />
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| *Maltodextrin glucosidase
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| **[[5bn7]] – EcAGS <br />
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| }}
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| == References == | | == References == |