Alpha-glucosidase: Difference between revisions

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Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky

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-<StructureSection load='3a4a' size='340' side='right' caption='Structure of yeast isomaltase complex with glucose (stick model) and Ca+2 ion (green) (PDB code [[3a4a]]).' scene='59/596427/Cv/1'>
+<StructureSection load='3a4a' size='340' side='right' caption='Structure of yeast isomaltase complex with α-D-glucose and Ca+2 ion (green) (PDB code [[3a4a]]).' scene='59/596427/Cv/1'>
 == Function ==
-'''Alpha glucosidase''' (AGS) or '''maltase''' beaks down the 1,4-α bonds in starch or disaccharides to produce glucose.  Maltase breaks down maltose.  '''Isomaltase''' breaks the 1,6 bond.<ref>PMID:18848471</ref>
+'''Alpha glucosidase''' (AGS) or '''maltase''' breaks down the 1,4-α bonds in starch or disaccharides to produce glucose.  '''Maltase''' breaks down maltose.  '''Isomaltase''' or '''sucrase-isomaltase''' or '''oligo-1,6-glucosidase''' breaks the 1,6 bond.<ref>PMID:18848471</ref>
+*'''Maltase-glucoamylase''' has important role in glucose production.  It hydrolize linear alpha-1,4-linked oligosaccharides<ref>PMID:22058037</ref>.<br />
+*'''Acid-alpha gucosidase''' degrades glycogen polymers to glucose in the acidic lysosomes<ref>PMID:17217857</ref>.<br />
+*'''6-phospho-alpha gucosidase''' hydrolyses maltose-6"-phosphate<ref>PMID:15341727</ref>.<br />
+*'''Glucan 1,4-alpha gucosidase''' hydrolyses the terminal 1,4-linked alpha-D-glucose residues in polysaccharides to produce beta-glucose.<br />
+For details see [[Sucrase-isomaltase]].
+See also [[Kennedy research]] and [[Carbohydrate Metabolism]].
 == Disease ==
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 AGS deficiency is the cause of Pompe Disease.  AGS inhibitors are used as anti-diabetic drugs and can potentially prevent the fusion of HIV and hepatitis B virus to cells.
-</StructureSection>
+== Structural highlights ==
+<scene name='59/596427/Cv/3'>α-D-glucose binding site</scene> (PDB code [[3a4a]]).<ref>PMID:20812985</ref> Water molecules shown as red spheres.
+<scene name='59/596427/Cv/5'>Ca coordination site</scene>.
 ==3D structures of α-glucosidase==
+[[Alpha-glucosidase 3D structures]]
-Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
+</StructureSection>
-{{#tree:id=OrganizedByTopic|openlevels=0|
-*Alpha glucosidase
-**[[2g3m]] – SsAGS – ''Sulfolobus solfataricus''<br />
-**[[2ze0]] – AGS – ''Geobacillus''<br />
-**[[3w38]] – bAGS - beet<br />
-**[[2d73]], [[2jka]], [[3wfa]] – BtAGS – ''Bacterioides thetaiotaomicron''<br />
-*Maltase complex
-**[[1vjt]] – TmAGS + NAD – ''Thermotoga maritima''<br />
-**[[1obb]] – TmAGS + NAD + maltose <br />
-**[[2g3n]] – SsAGS + octylglucoside<br />
-**[[3w37]] – bAGS + acarbose <br />
-**[[3wel]], [[3wem]], [[3wen]], [[3weo]] – bAGS + acarviosyl-maltooligosaccharide <br />
-*Isomaltase
-**[[3a47]], [[3aj7]] – yAGS – yeast<br />
-**[[3a4a]], [[3axh]] – yAGS + glucose<br />
-**[[3axi]] – yAGS (mutant) + glucose<br />
-**[[3n04]] – RoAGS – ''Ruminococcus obeum''<br />
-**[[3nsx]], [[3nuk]] – RoAGS (mutant)<br />
-**[[3pha]], [[3poc]] – RoAGS (mutant) + acarbose<br />
-**[[3mkk]] – RoAGS + isomaltose <br />
-*Alpha-glucosidase complex
-**[[2jke]] – BtAGS + deoxynojirimycin<br />
-**[[2jkp]] – BtAGS + castasnospermine<br />
-**[[2zq0]] – BtAGS + acarbose<br />
-}}
 == References ==