2dil: Difference between revisions

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-{{Seed}}
-[[Image:2dil.png|left|200px]]
-<!--
+==Solution structure of the SH3 domain of the human Proline-serine-threonine phosphatase-interacting protein 1==
-The line below this paragraph, containing "STRUCTURE_2dil", creates the "Structure Box" on the page.
+<StructureSection load='2dil' size='340' side='right'caption='[[2dil]]' scene=''>
-You may change the PDB parameter (which sets the PDB file loaded into the applet)
+== Structural highlights ==
-or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+<table><tr><td colspan='2'>[[2dil]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DIL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2DIL FirstGlance]. <br>
-or leave the SCENE parameter empty for the default display.
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
--->
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2dil FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2dil OCA], [https://pdbe.org/2dil PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2dil RCSB], [https://www.ebi.ac.uk/pdbsum/2dil PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2dil ProSAT], [https://www.topsan.org/Proteins/RSGI/2dil TOPSAN]</span></td></tr>
-{{STRUCTURE_2dil|  PDB=2dil  |  SCENE=  }}
+</table>
+== Disease ==
-===Solution structure of the SH3 domain of the human Proline-serine-threonine phosphatase-interacting protein 1===
+[https://www.uniprot.org/uniprot/PPIP1_HUMAN PPIP1_HUMAN] Defects in PSTPIP1 are the cause of PAPA syndrome (PAPAS) [MIM:[https://omim.org/entry/604416 604416]; also known as pyogenic sterile arthritis, pyoderma gangrenosum and acne or familial recurrent arthritis (FRA). PAPAS is characterized by autosomal dominant inheritance of early onset, primarily affecting skin and joint tissues. Recurring inflammatory episodes lead to accumulation of sterile, pyogenic, neutrophil-rich material within the affected joints, ultimately resulting in significant destruction.<ref>PMID:14595024</ref> <ref>PMID:11971877</ref>
+== Function ==
+[https://www.uniprot.org/uniprot/PPIP1_HUMAN PPIP1_HUMAN] Involved in regulation of the actin cytoskeleton. May regulate the WAS actin-bundling activity. Bridges the interaction between ABL1 and PTPN18 leading to the ABL1 dephosphorylation. May play a role as a scaffold protein between PTPN12 and WAS and allows PTPN12 to dephosphorylate WAS. Has the potential to physically couple CD2 and CD2AP to WAS. Acts downstream of CD2 and CD2AP to recruit WAS to the T-cell:APC contact site so as to promote the actin polymerization required for synapse induction during T-cell activation (By similarity). Down-regulates CD2-stimulated adhesion through the coupling of PTPN12 to CD2.<ref>PMID:9857189</ref>
-==About this Structure==
+== Evolutionary Conservation ==
-DIL is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DIL OCA].
+[[Image:Consurf_key_small.gif|200px|right]]
+Check<jmol>
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/di/2dil_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2dil ConSurf].
+<div style="clear:both"></div>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
 [[Category: Homo sapiens]]
-[[Category: Inoue, M.]]
+[[Category: Large Structures]]
-[[Category: Kigawa, T.]]
+[[Category: Inoue M]]
-[[Category: Koshiba, S.]]
+[[Category: Kigawa T]]
-[[Category: RSGI, RIKEN Structural Genomics/Proteomics Initiative.]]
+[[Category: Koshiba S]]
-[[Category: Tochio, N.]]
+[[Category: Tochio N]]
-[[Category: Yokoyama, S.]]
+[[Category: Yokoyama S]]
-[[Category: Yoneyama, M.]]
+[[Category: Yoneyama M]]
-[[Category: Cd2-binding protein 1]]
-[[Category: Cell adhesion]]
-[[Category: National project on protein structural and functional analyse]]
-[[Category: Nppsfa]]
-[[Category: Pest phosphatase-interacting protein 1]]
-[[Category: Riken structural genomics/proteomics initiative]]
-[[Category: Rsgi]]
-[[Category: Sh3 domain]]
-[[Category: Structural genomic]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Nov 16 16:57:26 2008''