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==Solution structure of the RNA binding domain in heterogeneous nuclear ribonucleoprotein F homolog== | |||
<StructureSection load='2db1' size='340' side='right'caption='[[2db1]]' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[2db1]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DB1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2DB1 FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2db1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2db1 OCA], [https://pdbe.org/2db1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2db1 RCSB], [https://www.ebi.ac.uk/pdbsum/2db1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2db1 ProSAT], [https://www.topsan.org/Proteins/RSGI/2db1 TOPSAN]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/HNRPF_MOUSE HNRPF_MOUSE] Component of the heterogeneous nuclear ribonucleoprotein (hnRNP) complexes which provide the substrate for the processing events that pre-mRNAs undergo before becoming functional, translatable mRNAs in the cytoplasm. Plays a role in the regulation of alternative splicing events. Binds G-rich sequences in pre-mRNAs and keeps target RNA in an unfolded state (By similarity). | |||
== Evolutionary Conservation == | |||
[[Image:Consurf_key_small.gif|200px|right]] | |||
Check<jmol> | |||
<jmolCheckbox> | |||
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/db/2db1_consurf.spt"</scriptWhenChecked> | |||
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | |||
<text>to colour the structure by Evolutionary Conservation</text> | |||
</jmolCheckbox> | |||
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2db1 ConSurf]. | |||
<div style="clear:both"></div> | |||
==See Also== | |||
*[[Nucleoprotein 3D structures|Nucleoprotein 3D structures]] | |||
__TOC__ | |||
== | </StructureSection> | ||
[[Category: Large Structures]] | |||
[[Category: Mus musculus]] | [[Category: Mus musculus]] | ||
[[Category: Abe C]] | |||
[[Category: Abe | [[Category: Inoue M]] | ||
[[Category: Inoue | [[Category: Kigawa T]] | ||
[[Category: Kigawa | [[Category: Muto Y]] | ||
[[Category: Muto | [[Category: Shirouzu M]] | ||
[[Category: Terada T]] | |||
[[Category: Shirouzu | [[Category: Yokoyama S]] | ||
[[Category: Terada | |||
[[Category: Yokoyama | |||
Latest revision as of 14:37, 22 May 2024
Solution structure of the RNA binding domain in heterogeneous nuclear ribonucleoprotein F homologSolution structure of the RNA binding domain in heterogeneous nuclear ribonucleoprotein F homolog
Structural highlights
FunctionHNRPF_MOUSE Component of the heterogeneous nuclear ribonucleoprotein (hnRNP) complexes which provide the substrate for the processing events that pre-mRNAs undergo before becoming functional, translatable mRNAs in the cytoplasm. Plays a role in the regulation of alternative splicing events. Binds G-rich sequences in pre-mRNAs and keeps target RNA in an unfolded state (By similarity). Evolutionary Conservation Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf. See Also |
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