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[[Image:2cz1.gif|left|200px]]


{{Structure
==photo-activation state of Fe-type NHase with n-BA in anaerobic condition==
|PDB= 2cz1 |SIZE=350|CAPTION= <scene name='initialview01'>2cz1</scene>, resolution 1.39&Aring;
<StructureSection load='2cz1' size='340' side='right'caption='[[2cz1]], [[Resolution|resolution]] 1.39&Aring;' scene=''>
|SITE=  
== Structural highlights ==
|LIGAND= <scene name='pdbligand=BUA:BUTANOIC+ACID'>BUA</scene>, <scene name='pdbligand=CSD:3-SULFINOALANINE'>CSD</scene>, <scene name='pdbligand=CSO:S-HYDROXYCYSTEINE'>CSO</scene>, <scene name='pdbligand=FE:FE+(III)+ION'>FE</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>
<table><tr><td colspan='2'>[[2cz1]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Rhodococcus_erythropolis Rhodococcus erythropolis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CZ1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2CZ1 FirstGlance]. <br>
|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Nitrile_hydratase Nitrile hydratase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.2.1.84 4.2.1.84] </span>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.39&#8491;</td></tr>
|GENE=
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BUA:BUTANOIC+ACID'>BUA</scene>, <scene name='pdbligand=CSD:3-SULFINOALANINE'>CSD</scene>, <scene name='pdbligand=CSO:S-HYDROXYCYSTEINE'>CSO</scene>, <scene name='pdbligand=FE:FE+(III)+ION'>FE</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
|DOMAIN=
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2cz1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cz1 OCA], [https://pdbe.org/2cz1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2cz1 RCSB], [https://www.ebi.ac.uk/pdbsum/2cz1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2cz1 ProSAT], [https://www.topsan.org/Proteins/RSGI/2cz1 TOPSAN]</span></td></tr>
|RELATEDENTRY=[[2cyz|2CYZ]], [[2cz0|2CZ0]]
</table>
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2cz1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cz1 OCA], [http://www.ebi.ac.uk/pdbsum/2cz1 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2cz1 RCSB]</span>
== Function ==
}}
[https://www.uniprot.org/uniprot/NHAA_RHOER NHAA_RHOER] NHase catalyzes the hydration of various nitrile compounds to the corresponding amides. Industrial production of acrylamide is now being developed using some of the enzymes of this class.
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/cz/2cz1_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2cz1 ConSurf].
<div style="clear:both"></div>


'''photo-activation state of Fe-type NHase with n-BA in anaerobic condition'''
==See Also==
 
*[[Nitrile hydratase|Nitrile hydratase]]
 
__TOC__
==About this Structure==
</StructureSection>
2CZ1 is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Rhodococcus_erythropolis Rhodococcus erythropolis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CZ1 OCA].
[[Category: Large Structures]]
[[Category: Nitrile hydratase]]
[[Category: Protein complex]]
[[Category: Rhodococcus erythropolis]]
[[Category: Rhodococcus erythropolis]]
[[Category: Endo, I.]]
[[Category: Endo I]]
[[Category: Hashimoto, K.]]
[[Category: Hashimoto K]]
[[Category: Kamiya, N.]]
[[Category: Kamiya N]]
[[Category: Kawano, Y.]]
[[Category: Kawano Y]]
[[Category: Nakayama, H.]]
[[Category: Nakayama H]]
[[Category: Odaka, M.]]
[[Category: Odaka M]]
[[Category: RSGI, RIKEN Structural Genomics/Proteomics Initiative.]]
[[Category: Takio K]]
[[Category: Takio, K.]]
[[Category: cysteine-sulfenic acid]]
[[Category: cysteine-sulfinic acid]]
[[Category: hydration]]
[[Category: national project on protein structural and functional analyse]]
[[Category: nitrile]]
[[Category: non-hem iron]]
[[Category: nppsfa]]
[[Category: photo-reactive]]
[[Category: post-translational modification]]
[[Category: riken structural genomics/proteomics initiative]]
[[Category: rsgi]]
[[Category: structural genomic]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 02:28:09 2008''

Latest revision as of 14:32, 22 May 2024

photo-activation state of Fe-type NHase with n-BA in anaerobic conditionphoto-activation state of Fe-type NHase with n-BA in anaerobic condition

Structural highlights

2cz1 is a 2 chain structure with sequence from Rhodococcus erythropolis. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 1.39Å
Ligands:, , , ,
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT, TOPSAN

Function

NHAA_RHOER NHase catalyzes the hydration of various nitrile compounds to the corresponding amides. Industrial production of acrylamide is now being developed using some of the enzymes of this class.

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

See Also

2cz1, resolution 1.39Å

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