2cw8: Difference between revisions

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-[[Image:2cw8.png|left|200px]]
-{{STRUCTURE_2cw8|  PDB=2cw8  |  SCENE=  }}
+==Crystal structure of intein homing endonuclease II==
+<StructureSection load='2cw8' size='340' side='right'caption='[[2cw8]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
-===Crystal structure of intein homing endonuclease II===
+== Structural highlights ==
+<table><tr><td colspan='2'>[[2cw8]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Thermococcus_kodakarensis_KOD1 Thermococcus kodakarensis KOD1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CW8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2CW8 FirstGlance]. <br>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5&#8491;</td></tr>
-==About this Structure==
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-[[2cw8]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Thermococcus_kodakarensis_kod1 Thermococcus kodakarensis kod1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CW8 OCA].
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2cw8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cw8 OCA], [https://pdbe.org/2cw8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2cw8 RCSB], [https://www.ebi.ac.uk/pdbsum/2cw8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2cw8 ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/DPOL_THEKO DPOL_THEKO] Intein encoded endonucleases are thought to mediate intein mobility by site-specific recombination initiated by endonuclease cleavage at the "homing site" in gene that lack the intein. PI-PkoI recognizes 5'-GATTTAGATCCCTGTACC-3' and PI-PkoII recognizes 5'-CAGCTACTACGGTTAC-3'.
+== Evolutionary Conservation ==
+[[Image:Consurf_key_small.gif|200px|right]]
+Check<jmol>
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/cw/2cw8_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2cw8 ConSurf].
+<div style="clear:both"></div>
 ==See Also==
-*[[Endonuclease|Endonuclease]]
+*[[Endonuclease 3D structures|Endonuclease 3D structures]]
+__TOC__
-==Reference==
+</StructureSection>
-<ref group="xtra">PMID:016493661</ref><references group="xtra"/>
+[[Category: Large Structures]]
-[[Category: Thermococcus kodakarensis kod1]]
+[[Category: Thermococcus kodakarensis KOD1]]
-[[Category: Fujiwara, S.]]
+[[Category: Fujiwara S]]
-[[Category: Hashimoto, H.]]
+[[Category: Hashimoto H]]
-[[Category: Imanaka, T.]]
+[[Category: Imanaka T]]
-[[Category: Inoue, T.]]
+[[Category: Inoue T]]
-[[Category: Kai, Y.]]
+[[Category: Kai Y]]
-[[Category: Matsumura, H.]]
+[[Category: Matsumura H]]
-[[Category: Nishioka, M.]]
+[[Category: Nishioka M]]
-[[Category: Takagi, M.]]
+[[Category: Takagi M]]
-[[Category: Takahashi, H.]]
+[[Category: Takahashi H]]
-[[Category: Hydrolase]]