2cu1: Difference between revisions

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA

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-[[Image:2cu1.gif|left|200px]]<br />
-<applet load="2cu1" size="450" color="white" frame="true" align="right" spinBox="true"
-caption="2cu1" />
-'''Solution structure of the PB1 domain of human protein kinase MEKK2b'''<br />
-==About this Structure==
+==Solution structure of the PB1 domain of human protein kinase MEKK2b==
-CU1 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Active as [http://en.wikipedia.org/wiki/Non-specific_serine/threonine_protein_kinase Non-specific serine/threonine protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.1 2.7.11.1] Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=2CU1 OCA].
+<StructureSection load='2cu1' size='340' side='right'caption='[[2cu1]]' scene=''>
+== Structural highlights ==
+<table><tr><td colspan='2'>[[2cu1]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CU1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2CU1 FirstGlance]. <br>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2cu1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cu1 OCA], [https://pdbe.org/2cu1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2cu1 RCSB], [https://www.ebi.ac.uk/pdbsum/2cu1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2cu1 ProSAT], [https://www.topsan.org/Proteins/RSGI/2cu1 TOPSAN]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/M3K2_HUMAN M3K2_HUMAN] Component of a protein kinase signal transduction cascade. Regulates the JNK and ERK5 pathways by phosphorylating and activating MAP2K5 and MAP2K7 (By similarity). Plays a role in caveolae kiss-and-run dynamics.<ref>PMID:10713157</ref> <ref>PMID:16001074</ref>
+== Evolutionary Conservation ==
+[[Image:Consurf_key_small.gif|200px|right]]
+Check<jmol>
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/cu/2cu1_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2cu1 ConSurf].
+<div style="clear:both"></div>
+==See Also==
+*[[Mitogen-activated protein kinase kinase kinase|Mitogen-activated protein kinase kinase kinase]]
+== References ==
+<references/>
+__TOC__
+</StructureSection>
 [[Category: Homo sapiens]]
-[[Category: Non-specific serine/threonine protein kinase]]
+[[Category: Large Structures]]
-[[Category: Single protein]]
+[[Category: Hayashi F]]
-[[Category: Hayashi, F.]]
+[[Category: Inoue K]]
-[[Category: Inoue, K.]]
+[[Category: Nagashima T]]
-[[Category: Nagashima, T.]]
+[[Category: Yokoyama S]]
-[[Category: RSGI, RIKEN.Structural.Genomics/Proteomics.Initiative.]]
-[[Category: Yokoyama, S.]]
-[[Category: mapk/erk kinase kinase 2]]
-[[Category: mek kinase 2]]
-[[Category: mekk 2]]
-[[Category: mitogen-activated protein kinase kinase kinase 2]]
-[[Category: national project on protein structural and functional analyses]]
-[[Category: nppsfa]]
-[[Category: pb1 domain]]
-[[Category: riken structural genomics/proteomics initiative]]
-[[Category: rsgi]]
-[[Category: signaling protein]]
-[[Category: structural genomics]]
-''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Mon Nov 12 21:23:45 2007''