2cs1: Difference between revisions

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-{{Seed}}
-[[Image:2cs1.png|left|200px]]
-<!--
+==Solution structure of the HMG domain of human DNA mismatch repair protein==
-The line below this paragraph, containing "STRUCTURE_2cs1", creates the "Structure Box" on the page.
+<StructureSection load='2cs1' size='340' side='right'caption='[[2cs1]]' scene=''>
-You may change the PDB parameter (which sets the PDB file loaded into the applet)
+== Structural highlights ==
-or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+<table><tr><td colspan='2'>[[2cs1]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CS1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2CS1 FirstGlance]. <br>
-or leave the SCENE parameter empty for the default display.
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
--->
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2cs1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cs1 OCA], [https://pdbe.org/2cs1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2cs1 RCSB], [https://www.ebi.ac.uk/pdbsum/2cs1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2cs1 ProSAT], [https://www.topsan.org/Proteins/RSGI/2cs1 TOPSAN]</span></td></tr>
-{{STRUCTURE_2cs1|  PDB=2cs1  |  SCENE=  }}
+</table>
+== Disease ==
+[https://www.uniprot.org/uniprot/PMS1_HUMAN PMS1_HUMAN] Defects in PMS1 are the cause of hereditary non-polyposis colorectal cancer type 3 (HNPCC3) [MIM:[https://omim.org/entry/600258 600258]. Mutations in more than one gene locus can be involved alone or in combination in the production of the HNPCC phenotype (also called Lynch syndrome). Most families with clinically recognized HNPCC have mutations in either MLH1 or MSH2 genes. HNPCC is an autosomal, dominantly inherited disease associated with marked increase in cancer susceptibility. It is characterized by a familial predisposition to early onset colorectal carcinoma (CRC) and extra-colonic cancers of the gastrointestinal, urological and female reproductive tracts. HNPCC is reported to be the most common form of inherited colorectal cancer in the Western world, and accounts for 15% of all colon cancers. Cancers in HNPCC originate within benign neoplastic polyps termed adenomas. Clinically, HNPCC is often divided into two subgroups. Type I: hereditary predisposition to colorectal cancer, a young age of onset, and carcinoma observed in the proximal colon. Type II: patients have an increased risk for cancers in certain tissues such as the uterus, ovary, breast, stomach, small intestine, skin, and larynx in addition to the colon. Diagnosis of classical HNPCC is based on the Amsterdam criteria: 3 or more relatives affected by colorectal cancer, one a first degree relative of the other two; 2 or more generation affected; 1 or more colorectal cancers presenting before 50 years of age; exclusion of hereditary polyposis syndromes. The term 'suspected HNPCC' or 'incomplete HNPCC' can be used to describe families who do not or only partially fulfill the Amsterdam criteria, but in whom a genetic basis for colon cancer is strongly suspected.<ref>PMID:10480359</ref>
+== Function ==
+[https://www.uniprot.org/uniprot/PMS1_HUMAN PMS1_HUMAN] Probably involved in the repair of mismatches in DNA.<ref>PMID:10748105</ref>
+== Evolutionary Conservation ==
+[[Image:Consurf_key_small.gif|200px|right]]
+Check<jmol>
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/cs/2cs1_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2cs1 ConSurf].
+<div style="clear:both"></div>
-===Solution structure of the HMG domain of human DNA mismatch repair protein===
+==See Also==
+*[[DNA mismatch repair protein 3D structures|DNA mismatch repair protein 3D structures]]
+== References ==
-==About this Structure==
+<references/>
-CS1 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CS1 OCA].
+__TOC__
+</StructureSection>
 [[Category: Homo sapiens]]
-[[Category: Single protein]]
+[[Category: Large Structures]]
-[[Category: Hayashi, F.]]
+[[Category: Hayashi F]]
-[[Category: Kurosaki, C.]]
+[[Category: Kurosaki C]]
-[[Category: RSGI, RIKEN Structural Genomics/Proteomics Initiative.]]
+[[Category: Yokoyama S]]
-[[Category: Yokoyama, S.]]
+[[Category: Yoshida M]]
-[[Category: Yoshida, M.]]
-[[Category: Dna mismatch repair protein pms1]]
-[[Category: National project on protein structural and functional analyse]]
-[[Category: Nppsfa]]
-[[Category: Riken structural genomics/proteomics initiative]]
-[[Category: Rsgi]]
-[[Category: Structural genomic]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Sep 29 06:47:01 2008''