2cqy: Difference between revisions

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA

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-[[Image:2cqy.gif|left|200px]]<br />
-<applet load="2cqy" size="450" color="white" frame="true" align="right" spinBox="true"
-caption="2cqy" />
-'''Solution structure of B domain from human propionyl-CoA carboxylase alpha subunit'''<br />
-==Disease==
+==Solution structure of B domain from human propionyl-CoA carboxylase alpha subunit==
-Known disease associated with this structure: Propionicacidemia OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=232000 232000]]
+<StructureSection load='2cqy' size='340' side='right'caption='[[2cqy]]' scene=''>
+== Structural highlights ==
-==About this Structure==
+<table><tr><td colspan='2'>[[2cqy]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CQY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2CQY FirstGlance]. <br>
-CQY is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Active as [http://en.wikipedia.org/wiki/Propionyl-CoA_carboxylase Propionyl-CoA carboxylase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.4.1.3 6.4.1.3] Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=2CQY OCA].
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2cqy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cqy OCA], [https://pdbe.org/2cqy PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2cqy RCSB], [https://www.ebi.ac.uk/pdbsum/2cqy PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2cqy ProSAT], [https://www.topsan.org/Proteins/RSGI/2cqy TOPSAN]</span></td></tr>
+</table>
+== Disease ==
+[https://www.uniprot.org/uniprot/PCCA_HUMAN PCCA_HUMAN] Defects in PCCA are the cause of propionic acidemia type I (PA-1) [MIM:[https://omim.org/entry/606054 606054]. PA-1 is a life-threatening disease characterized by episodic vomiting, lethargy and ketosis, neutropenia, periodic thrombocytopenia, hypogammaglobulinemia, developmental retardation, and intolerance to protein.<ref>PMID:10101253</ref> <ref>PMID:12559849</ref> <ref>PMID:15059621</ref> <ref>PMID:10329019</ref>
+== Function ==
+[https://www.uniprot.org/uniprot/PCCA_HUMAN PCCA_HUMAN]
+== Evolutionary Conservation ==
+[[Image:Consurf_key_small.gif|200px|right]]
+Check<jmol>
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/cq/2cqy_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2cqy ConSurf].
+<div style="clear:both"></div>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
 [[Category: Homo sapiens]]
-[[Category: Propionyl-CoA carboxylase]]
+[[Category: Large Structures]]
-[[Category: Single protein]]
+[[Category: Hayashi F]]
-[[Category: Hayashi, F.]]
+[[Category: Suetake T]]
-[[Category: RSGI, RIKEN.Structural.Genomics/Proteomics.Initiative.]]
+[[Category: Yokoyama S]]
-[[Category: Suetake, T.]]
-[[Category: Yokoyama, S.]]
-[[Category: b domain]]
-[[Category: national project on protein structural and functional analyses]]
-[[Category: nppsfa]]
-[[Category: pcca]]
-[[Category: riken structural genomics/proteomics initiative]]
-[[Category: rsgi]]
-[[Category: structural genomics]]
-''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Mon Nov 12 21:20:55 2007''