2cp3: Difference between revisions

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[[Image:2cp3.png|left|200px]]


<!--
==Solution structure of the 2nd CAP-Gly domain in human CLIP-115/CYLN2==
The line below this paragraph, containing "STRUCTURE_2cp3", creates the "Structure Box" on the page.
<StructureSection load='2cp3' size='340' side='right'caption='[[2cp3]]' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[2cp3]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CP3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2CP3 FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2cp3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cp3 OCA], [https://pdbe.org/2cp3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2cp3 RCSB], [https://www.ebi.ac.uk/pdbsum/2cp3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2cp3 ProSAT], [https://www.topsan.org/Proteins/RSGI/2cp3 TOPSAN]</span></td></tr>
{{STRUCTURE_2cp3|  PDB=2cp3  |  SCENE=  }}
</table>
 
== Disease ==
===Solution structure of the 2nd CAP-Gly domain in human CLIP-115/CYLN2===
[https://www.uniprot.org/uniprot/CLIP2_HUMAN CLIP2_HUMAN] Williams syndrome. CLIP2 is located in the Williams-Beuren syndrome (WBS) critical region. WBS results from a hemizygous deletion of several genes on chromosome 7q11.23, thought to arise as a consequence of unequal crossing over between highly homologous low-copy repeat sequences flanking the deleted region. Haploinsufficiency of CLIP2 may be the cause of certain cardiovascular and musculo-skeletal abnormalities observed in the disease.
 
== Function ==
 
[https://www.uniprot.org/uniprot/CLIP2_HUMAN CLIP2_HUMAN] Seems to link microtubules to dendritic lamellar body (DLB), a membranous organelle predominantly present in bulbous dendritic appendages of neurons linked by dendrodendritic gap junctions. May operate in the control of brain-specific organelle translocations (By similarity).
==About this Structure==
== Evolutionary Conservation ==
[[2cp3]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CP3 OCA].  
[[Image:Consurf_key_small.gif|200px|right]]
 
Check<jmol>
==See Also==
  <jmolCheckbox>
*[[CAP-Gly domain|CAP-Gly domain]]
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/cp/2cp3_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2cp3 ConSurf].
<div style="clear:both"></div>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Inoue, M.]]
[[Category: Large Structures]]
[[Category: Kigawa, T.]]
[[Category: Inoue M]]
[[Category: Koshiba, S.]]
[[Category: Kigawa T]]
[[Category: RSGI, RIKEN Structural Genomics/Proteomics Initiative.]]
[[Category: Koshiba S]]
[[Category: Saito, K.]]
[[Category: Saito K]]
[[Category: Yokoyama, S.]]
[[Category: Yokoyama S]]
[[Category: Cyln2]]
[[Category: Cytoskeleton associated protein]]
[[Category: Kiaa0291]]
[[Category: Microtubule binding]]
[[Category: National project on protein structural and functional analyse]]
[[Category: Nppsfa]]
[[Category: Protein binding]]
[[Category: Riken structural genomics/proteomics initiative]]
[[Category: Rsgi]]
[[Category: Structural genomic]]

Latest revision as of 14:28, 22 May 2024

Solution structure of the 2nd CAP-Gly domain in human CLIP-115/CYLN2Solution structure of the 2nd CAP-Gly domain in human CLIP-115/CYLN2

Structural highlights

2cp3 is a 1 chain structure with sequence from Homo sapiens. Full experimental information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:Solution NMR
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT, TOPSAN

Disease

CLIP2_HUMAN Williams syndrome. CLIP2 is located in the Williams-Beuren syndrome (WBS) critical region. WBS results from a hemizygous deletion of several genes on chromosome 7q11.23, thought to arise as a consequence of unequal crossing over between highly homologous low-copy repeat sequences flanking the deleted region. Haploinsufficiency of CLIP2 may be the cause of certain cardiovascular and musculo-skeletal abnormalities observed in the disease.

Function

CLIP2_HUMAN Seems to link microtubules to dendritic lamellar body (DLB), a membranous organelle predominantly present in bulbous dendritic appendages of neurons linked by dendrodendritic gap junctions. May operate in the control of brain-specific organelle translocations (By similarity).

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

Drag the structure with the mouse to rotate

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OCA
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