2btf: Difference between revisions

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-{{Seed}}
-[[Image:2btf.png|left|200px]]
-<!--
+==THE STRUCTURE OF CRYSTALLINE PROFILIN-BETA-ACTIN==
-The line below this paragraph, containing "STRUCTURE_2btf", creates the "Structure Box" on the page.
+<StructureSection load='2btf' size='340' side='right'caption='[[2btf]], [[Resolution|resolution]] 2.55&Aring;' scene=''>
-You may change the PDB parameter (which sets the PDB file loaded into the applet)
+== Structural highlights ==
-or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+<table><tr><td colspan='2'>[[2btf]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BTF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2BTF FirstGlance]. <br>
-or leave the SCENE parameter empty for the default display.
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.55&#8491;</td></tr>
--->
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene>, <scene name='pdbligand=ATP:ADENOSINE-5-TRIPHOSPHATE'>ATP</scene>, <scene name='pdbligand=HIC:4-METHYL-HISTIDINE'>HIC</scene>, <scene name='pdbligand=SR:STRONTIUM+ION'>SR</scene></td></tr>
-{{STRUCTURE_2btf|  PDB=2btf  |  SCENE=  }}
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2btf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2btf OCA], [https://pdbe.org/2btf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2btf RCSB], [https://www.ebi.ac.uk/pdbsum/2btf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2btf ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/ACTB_BOVIN ACTB_BOVIN] Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.
+== Evolutionary Conservation ==
+[[Image:Consurf_key_small.gif|200px|right]]
+Check<jmol>
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/bt/2btf_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2btf ConSurf].
+<div style="clear:both"></div>
+<div style="background-color:#fffaf0;">
+== Publication Abstract from PubMed ==
+The three-dimensional structure of bovine profilin-beta-actin has been solved to 2.55 A resolution by X-ray crystallography. There are several significant local changes in the structure of beta-actin compared with alpha-actin as well as an overall 5 degrees rotation between its two major domains. Actin molecules in the crystal are organized into ribbons through intermolecular contacts like those found in oligomeric protein assemblies. Profilin forms two extensive contacts with the actin ribbon, one of which appears to correspond to the solution contact in vitro.
-===THE STRUCTURE OF CRYSTALLINE PROFILIN-BETA-ACTIN===
+The structure of crystalline profilin-beta-actin.,Schutt CE, Myslik JC, Rozycki MD, Goonesekere NC, Lindberg U Nature. 1993 Oct 28;365(6449):810-6. PMID:8413665<ref>PMID:8413665</ref>
+From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
+</div>
+<div class="pdbe-citations 2btf" style="background-color:#fffaf0;"></div>
-<!--
+==See Also==
-The line below this paragraph, {{ABSTRACT_PUBMED_8413665}}, adds the Publication Abstract to the page
+*[[Actin|Actin]]
-(as it appears on PubMed at http://www.pubmed.gov), where 8413665 is the PubMed ID number.
+*[[Actin 3D structures|Actin 3D structures]]
--->
+*[[Profilin 3D Structures|Profilin 3D Structures]]
-{{ABSTRACT_PUBMED_8413665}}
+== References ==
+<references/>
-==About this Structure==
+__TOC__
-BTF is a 2 chains structure of sequences from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BTF OCA].
+</StructureSection>
-==Reference==
-<ref group="xtra">PMID:8413665</ref><references group="xtra"/>
 [[Category: Bos taurus]]
-[[Category: Goonesekere, N C.W.]]
+[[Category: Large Structures]]
-[[Category: Myslik, J C.]]
+[[Category: Goonesekere NCW]]
-[[Category: Rozycki, M D.]]
+[[Category: Myslik JC]]
-[[Category: Schutt, C E.]]
+[[Category: Rozycki MD]]
-[[Category: Acetylation and actin-binding]]
+[[Category: Schutt CE]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Feb 16 10:56:00 2009''