7g8f: Difference between revisions

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-'''Unreleased structure'''
-The entry 7g8f is ON HOLD
+==ARHGEF2 PanDDA analysis group deposition -- ARHGEF2 and RhoA in complex with Z1079168976==
+<StructureSection load='7g8f' size='340' side='right'caption='[[7g8f]], [[Resolution|resolution]] 1.42&Aring;' scene=''>
+== Structural highlights ==
+<table><tr><td colspan='2'>[[7g8f]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7G8F OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7G8F FirstGlance]. <br>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.42&#8491;</td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=FMT:FORMIC+ACID'>FMT</scene>, <scene name='pdbligand=YXK:[1-(2,2,2-trifluoroethyl)-1H-imidazol-2-yl]acetonitrile'>YXK</scene></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7g8f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7g8f OCA], [https://pdbe.org/7g8f PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7g8f RCSB], [https://www.ebi.ac.uk/pdbsum/7g8f PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7g8f ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/RHOA_HUMAN RHOA_HUMAN] Regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal adhesions and actin stress fibers. Involved in a microtubule-dependent signal that is required for the myosin contractile ring formation during cell cycle cytokinesis. Plays an essential role in cleavage furrow formation. Required for the apical junction formation of keratinocyte cell-cell adhesion. Serves as a target for the yopT cysteine peptidase from Yersinia pestis, vector of the plague, and Yersinia pseudotuberculosis, which causes gastrointestinal disorders. Stimulates PKN2 kinase activity. May be an activator of PLCE1. Activated by ARHGEF2, which promotes the exchange of GDP for GTP. Essential for the SPATA13-mediated regulation of cell migration and adhesion assembly and disassembly. The MEMO1-RHOA-DIAPH1 signaling pathway plays an important role in ERBB2-dependent stabilization of microtubules at the cell cortex. It controls the localization of APC and CLASP2 to the cell membrane, via the regulation of GSK3B activity. In turn, membrane-bound APC allows the localization of the MACF1 to the cell membrane, which is required for microtubule capture and stabilization.<ref>PMID:8910519</ref> <ref>PMID:9121475</ref> <ref>PMID:12900402</ref> <ref>PMID:16103226</ref> <ref>PMID:16236794</ref> <ref>PMID:19934221</ref> <ref>PMID:20937854</ref> <ref>PMID:20974804</ref>
-Authors: Bradshaw, W.J., Katis, V.L., Bountra, C., von Delft, F., Brennan, P.E.
+==See Also==
+*[[Rho guanine nucleotide exchange factor 3D structures|Rho guanine nucleotide exchange factor 3D structures]]
-Description: ARHGEF2 PanDDA analysis group deposition --ARHGEF2 and RhoA in complex with Z1079168976
+== References ==
-[[Category: Unreleased Structures]]
+<references/>
-[[Category: Katis, V.L]]
+__TOC__
-[[Category: Von Delft, F]]
+</StructureSection>
-[[Category: Bountra, C]]
+[[Category: Homo sapiens]]
-[[Category: Brennan, P.E]]
+[[Category: Large Structures]]
-[[Category: Bradshaw, W.J]]
+[[Category: Bountra C]]
+[[Category: Bradshaw WJ]]
+[[Category: Brennan PE]]
+[[Category: Katis VL]]
+[[Category: Von Delft F]]