7frs: Difference between revisions

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'''Unreleased structure'''


The entry 7frs is ON HOLD
==PanDDA analysis group deposition of ground-state model of PTP1B==
<StructureSection load='7frs' size='340' side='right'caption='[[7frs]], [[Resolution|resolution]] 1.83&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[7frs]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7FRS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7FRS FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.83&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=TRS:2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL'>TRS</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7frs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7frs OCA], [https://pdbe.org/7frs PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7frs RCSB], [https://www.ebi.ac.uk/pdbsum/7frs PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7frs ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/PTN1_HUMAN PTN1_HUMAN] Tyrosine-protein phosphatase which acts as a regulator of endoplasmic reticulum unfolded protein response. Mediates dephosphorylation of EIF2AK3/PERK; inactivating the protein kinase activity of EIF2AK3/PERK. May play an important role in CKII- and p60c-src-induced signal transduction cascades. May regulate the EFNA5-EPHA3 signaling pathway which modulates cell reorganization and cell-cell repulsion.<ref>PMID:21135139</ref> <ref>PMID:22169477</ref>


Authors: Mehlman, T., Biel, J., Azeem, S.M., Nelson, E.R., Hossain, S., Dunnett, L.E., Paterson, N.G., Douangamath, A., Talon, R., Axford, D., Orins, H., von Delft, F., Keedy, D.A.
==See Also==
 
*[[Tyrosine phosphatase 3D structures|Tyrosine phosphatase 3D structures]]
Description: PanDDA analysis group deposition of ground-state model of PTP1B
== References ==
[[Category: Unreleased Structures]]
<references/>
[[Category: Mehlman, T]]
__TOC__
[[Category: Biel, J]]
</StructureSection>
[[Category: Nelson, E.R]]
[[Category: Homo sapiens]]
[[Category: Azeem, S.M]]
[[Category: Large Structures]]
[[Category: Paterson, N.G]]
[[Category: Axford D]]
[[Category: Dunnett, L.E]]
[[Category: Azeem SM]]
[[Category: Talon, R]]
[[Category: Biel J]]
[[Category: Keedy, D.A]]
[[Category: Douangamath A]]
[[Category: Douangamath, A]]
[[Category: Dunnett LE]]
[[Category: Hossain, S]]
[[Category: Hossain S]]
[[Category: Orins, H]]
[[Category: Keedy DA]]
[[Category: Von Delft, F]]
[[Category: Mehlman T]]
[[Category: Axford, D]]
[[Category: Nelson ER]]
[[Category: Orins H]]
[[Category: Paterson NG]]
[[Category: Talon R]]
[[Category: Von Delft F]]

Latest revision as of 13:31, 22 May 2024

PanDDA analysis group deposition of ground-state model of PTP1BPanDDA analysis group deposition of ground-state model of PTP1B

Structural highlights

7frs is a 1 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 1.83Å
Ligands:
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

PTN1_HUMAN Tyrosine-protein phosphatase which acts as a regulator of endoplasmic reticulum unfolded protein response. Mediates dephosphorylation of EIF2AK3/PERK; inactivating the protein kinase activity of EIF2AK3/PERK. May play an important role in CKII- and p60c-src-induced signal transduction cascades. May regulate the EFNA5-EPHA3 signaling pathway which modulates cell reorganization and cell-cell repulsion.[1] [2]

See Also

References

  1. ↑ Nievergall E, Janes PW, Stegmayer C, Vail ME, Haj FG, Teng SW, Neel BG, Bastiaens PI, Lackmann M. PTP1B regulates Eph receptor function and trafficking. J Cell Biol. 2010 Dec 13;191(6):1189-203. doi: 10.1083/jcb.201005035. Epub 2010, Dec 6. PMID:21135139 doi:10.1083/jcb.201005035
  2. ↑ Krishnan N, Fu C, Pappin DJ, Tonks NK. H2S-Induced sulfhydration of the phosphatase PTP1B and its role in the endoplasmic reticulum stress response. Sci Signal. 2011 Dec 13;4(203):ra86. doi: 10.1126/scisignal.2002329. PMID:22169477 doi:10.1126/scisignal.2002329

7frs, resolution 1.83Å

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