7fri: Difference between revisions

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-'''Unreleased structure'''
-The entry 7fri is ON HOLD
+==PanDDA analysis group deposition -- Crystal structure of PTP1B in complex with Z321318226==
+<StructureSection load='7fri' size='340' side='right'caption='[[7fri]], [[Resolution|resolution]] 1.86&Aring;' scene=''>
+== Structural highlights ==
+<table><tr><td colspan='2'>[[7fri]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7FRI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7FRI FirstGlance]. <br>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.86&#8491;</td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=JHJ:N-(4-methoxyphenyl)-N-pyridin-4-ylurea'>JHJ</scene>, <scene name='pdbligand=TRS:2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL'>TRS</scene></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7fri FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7fri OCA], [https://pdbe.org/7fri PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7fri RCSB], [https://www.ebi.ac.uk/pdbsum/7fri PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7fri ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/PTN1_HUMAN PTN1_HUMAN] Tyrosine-protein phosphatase which acts as a regulator of endoplasmic reticulum unfolded protein response. Mediates dephosphorylation of EIF2AK3/PERK; inactivating the protein kinase activity of EIF2AK3/PERK. May play an important role in CKII- and p60c-src-induced signal transduction cascades. May regulate the EFNA5-EPHA3 signaling pathway which modulates cell reorganization and cell-cell repulsion.<ref>PMID:21135139</ref> <ref>PMID:22169477</ref>
-Authors: Mehlman, T., Biel, J., Azeem, S.M., Nelson, E.R., Hossain, S., Dunnett, L.E., Paterson, N.G., Douangamath, A., Talon, R., Axford, D., Orins, H., von Delft, F., Keedy, D.A.
+==See Also==
+*[[Tyrosine phosphatase 3D structures|Tyrosine phosphatase 3D structures]]
-Description: PanDDA analysis group deposition --Crystal structure of PTP1B in complex with Z321318226
+== References ==
-[[Category: Unreleased Structures]]
+<references/>
-[[Category: Mehlman, T]]
+__TOC__
-[[Category: Biel, J]]
+</StructureSection>
-[[Category: Nelson, E.R]]
+[[Category: Homo sapiens]]
-[[Category: Azeem, S.M]]
+[[Category: Large Structures]]
-[[Category: Paterson, N.G]]
+[[Category: Axford D]]
-[[Category: Dunnett, L.E]]
+[[Category: Azeem SM]]
-[[Category: Talon, R]]
+[[Category: Biel J]]
-[[Category: Keedy, D.A]]
+[[Category: Douangamath A]]
-[[Category: Douangamath, A]]
+[[Category: Dunnett LE]]
-[[Category: Hossain, S]]
+[[Category: Hossain S]]
-[[Category: Orins, H]]
+[[Category: Keedy DA]]
-[[Category: Von Delft, F]]
+[[Category: Mehlman T]]
-[[Category: Axford, D]]
+[[Category: Nelson ER]]
+[[Category: Orins H]]
+[[Category: Paterson NG]]
+[[Category: Talon R]]
+[[Category: Von Delft F]]