2l23: Difference between revisions

<StructureSection load='2l23' size='340' side='right'caption='[[2l23]]' scene=''>

<table><tr><td colspan='2'>[[2l23]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2L23 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2L23 FirstGlance]. <br>

</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2l23 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2l23 OCA], [https://pdbe.org/2l23 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2l23 RCSB], [https://www.ebi.ac.uk/pdbsum/2l23 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2l23 ProSAT]</span></td></tr>

[https://www.uniprot.org/uniprot/MED25_HUMAN MED25_HUMAN] Charcot-Marie-Tooth disease type 2B2. The disease is caused by mutations affecting the gene represented in this entry.<ref>PMID:19290556</ref>  

[https://www.uniprot.org/uniprot/MED25_HUMAN MED25_HUMAN] Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. Required for RARA/RXRA-mediated transcription.<ref>PMID:14657022</ref> <ref>PMID:14983011</ref> <ref>PMID:17641689</ref>  

[[Category: Homo sapiens]]

[[Category: Large Structures]]

[[Category: Bontems F]]

[[Category: Dewitte F]]

[[Category: Monte D]]

[[Category: Villeret V]]