2kom: Difference between revisions

<StructureSection load='2kom' size='340' side='right'caption='[[2kom]]' scene=''>

<table><tr><td colspan='2'>[[2kom]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KOM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2KOM FirstGlance]. <br>

</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2kom FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2kom OCA], [https://pdbe.org/2kom PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2kom RCSB], [https://www.ebi.ac.uk/pdbsum/2kom PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2kom ProSAT]</span></td></tr>

[https://www.uniprot.org/uniprot/PARD3_HUMAN PARD3_HUMAN] Adapter protein involved in asymmetrical cell division and cell polarization processes. Seems to play a central role in the formation of epithelial tight junctions. Targets the phosphatase PTEN to cell junctions (By similarity). Association with PARD6B may prevent the interaction of PARD3 with F11R/JAM1, thereby preventing tight junction assembly. The PARD6-PARD3 complex links GTP-bound Rho small GTPases to atypical protein kinase C proteins. Required for establishment of neuronal polarity and normal axon formation in cultured hippocampal neurons.<ref>PMID:19812038</ref>  

[[Category: Homo sapiens]]

[[Category: Large Structures]]

[[Category: Peterson FC]]

[[Category: Tyler RC]]

[[Category: Volkman BF]]