2kgr: Difference between revisions

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-'''Unreleased structure'''
-The entry 2kgr is ON HOLD
+==Solution structure of protein ITSN1 from Homo sapiens. Northeast Structural Genomics Consortium target HR5524A==
+<StructureSection load='2kgr' size='340' side='right'caption='[[2kgr]]' scene=''>
+== Structural highlights ==
+<table><tr><td colspan='2'>[[2kgr]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KGR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2KGR FirstGlance]. <br>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2kgr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2kgr OCA], [https://pdbe.org/2kgr PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2kgr RCSB], [https://www.ebi.ac.uk/pdbsum/2kgr PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2kgr ProSAT], [https://www.topsan.org/Proteins/NESGC/2kgr TOPSAN]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/ITSN1_HUMAN ITSN1_HUMAN] Adapter protein that may provide indirect link between the endocytic membrane traffic and the actin assembly machinery. May regulate the formation of clathrin-coated vesicles. Involved in endocytosis of integrin beta-1 (ITGB1) and transferrin receptor (TFR); internalization of ITGB1 as DAB2-dependent cargo but not TFR may involve association with DAB2. Isoform 1 could be involved in brain-specific synaptic vesicle recycling. Inhibits ARHGAP31 activity toward RAC1.<ref>PMID:11744688</ref> <ref>PMID:22648170</ref>
+== Evolutionary Conservation ==
+[[Image:Consurf_key_small.gif|200px|right]]
+Check<jmol>
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/kg/2kgr_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2kgr ConSurf].
+<div style="clear:both"></div>
-Authors: Wu, Y., Ghosh, A., Shastry, R., Hua, J., Ciccosanti, C., Zhang, Q., Jiang, M., Swapna, G., Acton, T., Xiao, R., Everett, J., Montelione, G., SZYPERSKI, T.
+==See Also==
+*[[Intersectin|Intersectin]]
-Description: Solution structure of protein ITSN1 from Homo sapiens. Northeast Structural Genomics Consortium target HR5524A
+== References ==
+<references/>
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Apr  9 12:14:48 2009''
+__TOC__
+</StructureSection>
+[[Category: Homo sapiens]]
+[[Category: Large Structures]]
+[[Category: Acton T]]
+[[Category: Ciccosanti C]]
+[[Category: Everett J]]
+[[Category: Ghosh A]]
+[[Category: Hua J]]
+[[Category: Jiang M]]
+[[Category: Montelione G]]
+[[Category: Shastry R]]
+[[Category: Swapna G]]
+[[Category: Szyperski T]]
+[[Category: Wu Y]]
+[[Category: Xiao R]]
+[[Category: Zhang Q]]