2k6v: Difference between revisions

← Older edit

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA

@@ Line 1: / Line 1: @@
-{{Seed}}
-[[Image:2k6v.png|left|200px]]
-<!--
+==Solution structures of apo Sco1 protein from Thermus Thermophilus==
-The line below this paragraph, containing "STRUCTURE_2k6v", creates the "Structure Box" on the page.
+<StructureSection load='2k6v' size='340' side='right'caption='[[2k6v]]' scene=''>
-You may change the PDB parameter (which sets the PDB file loaded into the applet)
+== Structural highlights ==
-or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+<table><tr><td colspan='2'>[[2k6v]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Thermus_thermophilus_HB8 Thermus thermophilus HB8]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2K6V OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2K6V FirstGlance]. <br>
-or leave the SCENE parameter empty for the default display.
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
--->
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2k6v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2k6v OCA], [https://pdbe.org/2k6v PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2k6v RCSB], [https://www.ebi.ac.uk/pdbsum/2k6v PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2k6v ProSAT]</span></td></tr>
-{{STRUCTURE_2k6v|  PDB=2k6v  |  SCENE=  }}
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/Q5SGY8_THET8 Q5SGY8_THET8]
+== Evolutionary Conservation ==
+[[Image:Consurf_key_small.gif|200px|right]]
+Check<jmol>
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/k6/2k6v_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2k6v ConSurf].
+<div style="clear:both"></div>
+<div style="background-color:#fffaf0;">
+== Publication Abstract from PubMed ==
+Copper is essential for proper functioning of cytochrome c oxidases, and therefore for cellular respiration in eukaryotes and many bacteria. Here we show that a new periplasmic protein (PCu(A)C) selectively inserts Cu(I) ions into subunit II of Thermus thermophilus ba(3) oxidase to generate a native Cu(A) site. The purported metallochaperone Sco1 is unable to deliver copper ions; instead, it works as a thiol-disulfide reductase to maintain the correct oxidation state of the Cu(A) cysteine ligands.
-===Solution structures of apo Sco1 protein from Thermus Thermophilus===
+Mechanism of Cu(A) assembly.,Abriata LA, Banci L, Bertini I, Ciofi-Baffoni S, Gkazonis P, Spyroulias GA, Vila AJ, Wang S Nat Chem Biol. 2008 Oct;4(10):599-601. Epub 2008 Aug 31. PMID:18758441<ref>PMID:18758441</ref>
+From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
-<!--
+</div>
-The line below this paragraph, {{ABSTRACT_PUBMED_18758441}}, adds the Publication Abstract to the page
+<div class="pdbe-citations 2k6v" style="background-color:#fffaf0;"></div>
-(as it appears on PubMed at http://www.pubmed.gov), where 18758441 is the PubMed ID number.
+== References ==
--->
+<references/>
-{{ABSTRACT_PUBMED_18758441}}
+__TOC__
+</StructureSection>
-==About this Structure==
+[[Category: Large Structures]]
-K6V is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Thermus_thermophilus Thermus thermophilus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2K6V OCA].
+[[Category: Thermus thermophilus HB8]]
+[[Category: Abriata LA]]
-==Reference==
+[[Category: Banci L]]
-<ref group="xtra">PMID:18758441</ref><references group="xtra"/>
+[[Category: Bertini I]]
-[[Category: Thermus thermophilus]]
+[[Category: Ciofi-Baffoni S]]
-[[Category: Abriata, L A.]]
+[[Category: Gkazonis P]]
-[[Category: Banci, L.]]
+[[Category: Spyroulias GA]]
-[[Category: Bertini, I.]]
+[[Category: Vila AJ]]
-[[Category: Ciofi-Baffoni, S.]]
+[[Category: Wang S]]
-[[Category: Gkazonis, P.]]
-[[Category: Spyroulias, G A.]]
-[[Category: Vila, A J.]]
-[[Category: Wang, S.]]
-[[Category: Electron transfer protein]]
-[[Category: Electron transport]]
-[[Category: Metal binding protein]]
-[[Category: Thioredoxin fold]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 21:02:13 2009''