1t2s: Difference between revisions

No edit summary
No edit summary
 
(3 intermediate revisions by the same user not shown)
Line 1: Line 1:


==Structural basis for 3' end recognition of nucleic acids by the Drosophila Argonaute 2 PAZ domain==
==Structural basis for 3' end recognition of nucleic acids by the Drosophila Argonaute 2 PAZ domain==
<StructureSection load='1t2s' size='340' side='right' caption='[[1t2s]], [[NMR_Ensembles_of_Models | 10 NMR models]]' scene=''>
<StructureSection load='1t2s' size='340' side='right'caption='[[1t2s]]' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[1t2s]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Drome Drome]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1T2S OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1T2S FirstGlance]. <br>
<table><tr><td colspan='2'>[[1t2s]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Drosophila_melanogaster Drosophila melanogaster]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1T2S OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1T2S FirstGlance]. <br>
</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1upo|1upo]]</td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1t2s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1t2s OCA], [http://pdbe.org/1t2s PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1t2s RCSB], [http://www.ebi.ac.uk/pdbsum/1t2s PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1t2s ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1t2s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1t2s OCA], [https://pdbe.org/1t2s PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1t2s RCSB], [https://www.ebi.ac.uk/pdbsum/1t2s PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1t2s ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/AGO2_DROME AGO2_DROME]] Essential for RNA interference (RNAi); double-stranded RNA induces potent and specific gene silencing. RNAi is mediated by the RNA-induced silencing complex (RISC), a sequence-specific, multicomponent nuclease that destroys or silences messenger RNAs homologous to the silencing trigger.<ref>PMID:11498593</ref>
[https://www.uniprot.org/uniprot/AGO2_DROME AGO2_DROME] Essential for RNA interference (RNAi); double-stranded RNA induces potent and specific gene silencing. RNAi is mediated by the RNA-induced silencing complex (RISC), a sequence-specific, multicomponent nuclease that destroys or silences messenger RNAs homologous to the silencing trigger.<ref>PMID:11498593</ref>  
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Line 30: Line 30:


==See Also==
==See Also==
*[[Argonaute|Argonaute]]
*[[Argonaute 3D structures|Argonaute 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Drome]]
[[Category: Drosophila melanogaster]]
[[Category: Izaurralde, E]]
[[Category: Large Structures]]
[[Category: Lingel, A]]
[[Category: Izaurralde E]]
[[Category: Sattler, M]]
[[Category: Lingel A]]
[[Category: Simon, B]]
[[Category: Sattler M]]
[[Category: Dna]]
[[Category: Simon B]]
[[Category: Nucleic acid binding protein]]
[[Category: Nucleic acid binding protein-dna complex]]

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA