1sxe: Difference between revisions

<StructureSection load='1sxe' size='340' side='right' caption='[[1sxe]], [[NMR_Ensembles_of_Models | 14 NMR models]]' scene=''>

<table><tr><td colspan='2'>[[1sxe]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SXE OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1SXE FirstGlance]. <br>

</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">ERG ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1sxe FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1sxe OCA], [http://pdbe.org/1sxe PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1sxe RCSB], [http://www.ebi.ac.uk/pdbsum/1sxe PDBsum]</span></td></tr>

[[http://www.uniprot.org/uniprot/ERG_HUMAN ERG_HUMAN]] Defects in ERG are a cause of Ewing sarcoma (ES) [MIM:[http://omim.org/entry/612219 612219]]. A highly malignant, metastatic, primitive small round cell tumor of bone and soft tissue that affects children and adolescents. It belongs to the Ewing sarcoma family of tumors, a group of morphologically heterogeneous neoplasms that share the same cytogenetic features. They are considered neural tumors derived from cells of the neural crest. Ewing sarcoma represents the less differentiated form of the tumors. Note=A chromosomal aberration involving ERG is found in patients with Erwing sarcoma. Translocation t(21;22)(q22;q12) with EWSR1.  Note=Chromosomal aberrations involving ERG have been found in acute myeloid leukemia (AML). Translocation t(16;21)(p11;q22) with FUS. Translocation t(X;21)(q25-26;q22) with ELF4.  

[[http://www.uniprot.org/uniprot/ERG_HUMAN ERG_HUMAN]] Transcriptional regulator. May participate in transcriptional regulation through the recruitment of SETDB1 histone methyltransferase and subsequent modification of local chromatin structure.  

     <scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/sx/1sxe_consurf.spt"</scriptWhenChecked>

</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].

[[Category: Human]]

[[Category: Gentile, L N]]

[[Category: MacIntosh, S E]]

[[Category: Mackereth, C D]]

[[Category: McIntosh, L P]]

[[Category: Schaerpf, M]]

[[Category: Slupsky, C M]]

[[Category: Alpha helical]]

[[Category: Transcription]]