1sb0: Difference between revisions

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 ==Solution structure of the KIX domain of CBP bound to the transactivation domain of c-Myb==
-<StructureSection load='1sb0' size='340' side='right' caption='[[1sb0]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
+<StructureSection load='1sb0' size='340' side='right'caption='[[1sb0]]' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[1sb0]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SB0 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1SB0 FirstGlance]. <br>
+<table><tr><td colspan='2'>[[1sb0]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SB0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1SB0 FirstGlance]. <br>
-</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">CBP ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice]), c-Myb ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
-<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1sb0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1sb0 OCA], [http://pdbe.org/1sb0 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1sb0 RCSB], [http://www.ebi.ac.uk/pdbsum/1sb0 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1sb0 ProSAT]</span></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1sb0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1sb0 OCA], [https://pdbe.org/1sb0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1sb0 RCSB], [https://www.ebi.ac.uk/pdbsum/1sb0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1sb0 ProSAT]</span></td></tr>
 </table>
 == Function ==
-[[http://www.uniprot.org/uniprot/CBP_MOUSE CBP_MOUSE]] Acetylates histones, giving a specific tag for transcriptional activation. Also acetylates non-histone proteins, like NCOA3 and FOXO1. Binds specifically to phosphorylated CREB and enhances its transcriptional activity toward cAMP-responsive genes. Acts as a coactivator of ALX1 in the presence of EP300 (By similarity).<ref>PMID:10207073</ref> <ref>PMID:11701890</ref> <ref>PMID:15220471</ref> <ref>PMID:16287980</ref>  [[http://www.uniprot.org/uniprot/MYB_MOUSE MYB_MOUSE]] Transcriptional activator; DNA-binding protein that specifically recognize the sequence 5'-YAAC[GT]G-3'. Plays an important role in the control of proliferation and differentiation of hematopoietic progenitor cells.
+[https://www.uniprot.org/uniprot/CBP_MOUSE CBP_MOUSE] Acetylates histones, giving a specific tag for transcriptional activation. Also acetylates non-histone proteins, like NCOA3 and FOXO1. Binds specifically to phosphorylated CREB and enhances its transcriptional activity toward cAMP-responsive genes. Acts as a coactivator of ALX1 in the presence of EP300 (By similarity).<ref>PMID:10207073</ref> <ref>PMID:11701890</ref> <ref>PMID:15220471</ref> <ref>PMID:16287980</ref>
 == Evolutionary Conservation ==
 [[Image:Consurf_key_small.gif|200px|right]]
@@ Line 30: / Line 30: @@
 ==See Also==
-*[[CREB-binding protein|CREB-binding protein]]
+*[[CREB-binding protein 3D structures|CREB-binding protein 3D structures]]
-*[[Transcriptional activator|Transcriptional activator]]
+*[[Transcriptional activator 3D structures|Transcriptional activator 3D structures]]
 == References ==
 <references/>
 __TOC__
 </StructureSection>
-[[Category: Lk3 transgenic mice]]
+[[Category: Large Structures]]
-[[Category: Dyson, H J]]
+[[Category: Mus musculus]]
-[[Category: Guzman, R N.De]]
+[[Category: De Guzman RN]]
-[[Category: Wright, P E]]
+[[Category: Dyson HJ]]
-[[Category: Zor, T]]
+[[Category: Wright PE]]
-[[Category: Constitutive activation]]
+[[Category: Zor T]]
-[[Category: Creb-binding protein]]
-[[Category: Kix]]
-[[Category: Lxxll motif]]
-[[Category: Myb]]
-[[Category: Transcription]]
-[[Category: Transcriptional activation]]