1s5r: Difference between revisions
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==Solution Structure of HBP1 SID-mSin3A PAH2 Complex== | ==Solution Structure of HBP1 SID-mSin3A PAH2 Complex== | ||
<StructureSection load='1s5r' size='340' side='right'caption='[[1s5r | <StructureSection load='1s5r' size='340' side='right'caption='[[1s5r]]' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[1s5r]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/ | <table><tr><td colspan='2'>[[1s5r]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1S5R OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1S5R FirstGlance]. <br> | ||
</td></tr><tr id=' | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1s5r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1s5r OCA], [https://pdbe.org/1s5r PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1s5r RCSB], [https://www.ebi.ac.uk/pdbsum/1s5r PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1s5r ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1s5r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1s5r OCA], [https://pdbe.org/1s5r PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1s5r RCSB], [https://www.ebi.ac.uk/pdbsum/1s5r PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1s5r ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
[https://www.uniprot.org/uniprot/HBP1_MOUSE HBP1_MOUSE] Transcriptional repressor that binds to the promoter region of target genes. Plays a role in the regulation of the cell cycle and of the Wnt pathway. Binds preferentially to the sequence 5'-TTCATTCATTCA-3'. Binding to the H1F0 promoter is enhanced by interaction with RB1. Disrupts the interaction between DNA and TCF4 (By similarity).<ref>PMID:9178770</ref> | |||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: | [[Category: Mus musculus]] | ||
[[Category: Cowley | [[Category: Cowley SM]] | ||
[[Category: Eisenman | [[Category: Eisenman RN]] | ||
[[Category: Huang | [[Category: Huang K]] | ||
[[Category: Kang | [[Category: Kang RS]] | ||
[[Category: Knoepfler | [[Category: Knoepfler PS]] | ||
[[Category: Laherty | [[Category: Laherty CD]] | ||
[[Category: Radhakrishnan | [[Category: Radhakrishnan I]] | ||
[[Category: Swanson | [[Category: Swanson KA]] | ||