1rpr: Difference between revisions

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-{{Seed}}
-[[Image:1rpr.png|left|200px]]
-<!--
+==THE STRUCTURE OF COLE1 ROP IN SOLUTION==
-The line below this paragraph, containing "STRUCTURE_1rpr", creates the "Structure Box" on the page.
+<StructureSection load='1rpr' size='340' side='right'caption='[[1rpr]]' scene=''>
-You may change the PDB parameter (which sets the PDB file loaded into the applet)
+== Structural highlights ==
-or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+<table><tr><td colspan='2'>[[1rpr]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1RPR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1RPR FirstGlance]. <br>
-or leave the SCENE parameter empty for the default display.
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
--->
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1rpr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1rpr OCA], [https://pdbe.org/1rpr PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1rpr RCSB], [https://www.ebi.ac.uk/pdbsum/1rpr PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1rpr ProSAT]</span></td></tr>
-{{STRUCTURE_1rpr|  PDB=1rpr  |  SCENE=  }}
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/ROP_ECOLX ROP_ECOLX] Regulates plasmid DNA replication by modulating the initiation of transcription of the primer RNA precursor. Processing of the precursor of the primer, RNAII, is inhibited by hydrogen bonding of RNAII to its complementary sequence in RNAI. ROP increases the affinity of RNAI for RNAII and thus decreases the rate of replication initiation events.
+== Evolutionary Conservation ==
+[[Image:Consurf_key_small.gif|200px|right]]
+Check<jmol>
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/rp/1rpr_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1rpr ConSurf].
+<div style="clear:both"></div>
+<div style="background-color:#fffaf0;">
+== Publication Abstract from PubMed ==
+The structure of the ColE1 repressor of primer (rop) protein in solution was determined from the proton nuclear magnetic resonance data by a combined use of distance geometry and restrained molecular dynamics calculations. A set of structures was determined with low internal energy and virtually no violations of the experimental distance restraints. Rop forms homodimers: Two helical hairpins are arranged as an antiparallel four helix bundle with a left-handed rope-like twist of the helix axes and with left-handed bundle topology. The very compact packing of the side chains in the helix interfaces of the rop coiled-coil structure may well account for its high stability. Overall, the solution structure is highly similar to the recently determined X-ray structure (Banner, D.W., Kokkinidis, M. and Tsernoglou, D. (1987) J. Mol. Biol., 196, 657-675), although there are minor differences in regions where packing forces appear to influence the crystal structure.
-===THE STRUCTURE OF COLE1 ROP IN SOLUTION===
+The structure of ColE1 rop in solution.,Eberle W, Pastore A, Sander C, Rosch P J Biomol NMR. 1991 May;1(1):71-82. PMID:1841691<ref>PMID:1841691</ref>
+From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
+</div>
+<div class="pdbe-citations 1rpr" style="background-color:#fffaf0;"></div>
-<!--
+==See Also==
-The line below this paragraph, {{ABSTRACT_PUBMED_1841691}}, adds the Publication Abstract to the page
+*[[Rop protein|Rop protein]]
-(as it appears on PubMed at http://www.pubmed.gov), where 1841691 is the PubMed ID number.
+== References ==
--->
+<references/>
-{{ABSTRACT_PUBMED_1841691}}
+__TOC__
+</StructureSection>
-==About this Structure==
-RPR is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1RPR OCA].
-==Reference==
-The structure of ColE1 rop in solution., Eberle W, Pastore A, Sander C, Rosch P, J Biomol NMR. 1991 May;1(1):71-82. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/1841691 1841691]
 [[Category: Escherichia coli]]
-[[Category: Single protein]]
+[[Category: Large Structures]]
-[[Category: Eberle, W.]]
+[[Category: Eberle W]]
-[[Category: Klaus, W.]]
+[[Category: Klaus W]]
-[[Category: Pastore, A.]]
+[[Category: Pastore A]]
-[[Category: Roesch, P.]]
+[[Category: Roesch P]]
-[[Category: Sander, C.]]
+[[Category: Sander C]]
-[[Category: Transcription regulation]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 16:00:43 2008''