1no8: Difference between revisions

<StructureSection load='1no8' size='340' side='right'caption='[[1no8]]' scene=''>

<table><tr><td colspan='2'>[[1no8]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NO8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1NO8 FirstGlance]. <br>

</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1no8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1no8 OCA], [https://pdbe.org/1no8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1no8 RCSB], [https://www.ebi.ac.uk/pdbsum/1no8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1no8 ProSAT]</span></td></tr>

[https://www.uniprot.org/uniprot/THOC4_MOUSE THOC4_MOUSE] Component of the THO subcomplex of the TREX complex. The TREX complex specifically associates with spliced mRNA and not with unspliced pre-mRNA. It is recruited to spliced mRNAs by a transcription-independent mechanism. Binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export. The recruitment occurs via an interaction between ALYREF/THOC4 and the cap-binding protein NCBP1. DDX39B functions as a bridge between ALYREF/THOC4 and the THO complex (By similarity).<ref>PMID:9119228</ref> <ref>PMID:10786854</ref>  Component of a splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junction on mRNAs. The EJC is a dynamic structure consisting of a few core proteins and several more peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. Plays a role in mRNA processing and export. Acts as chaperone and promotes the dimerization of transcription factors containing basic leucine zipper (bZIP) domains and thereby promotes transcriptional activation. May function as scaffold that mediates interactions between proteins and/or RNA. Integral part of the THO/TREX complex that is recruited to transcribed genes and travels with the RNA polymerase during elongation. Is part of the exon junction complex that remains associated with spliced mRNA and plays an important role in mRNA export and nonsense-mediated RNA decay (By similarity).<ref>PMID:9119228</ref> <ref>PMID:10786854</ref>  

[[Category: Mus musculus]]

[[Category: Allen MM]]

[[Category: Dyson HJ]]

[[Category: Grosschedl R]]

[[Category: Martinez-Yamout M]]

[[Category: Perez-Alvarado GC]]

[[Category: Wright PE]]