1n72: Difference between revisions
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==Structure and Ligand of a Histone Acetyltransferase Bromodomain== | ==Structure and Ligand of a Histone Acetyltransferase Bromodomain== | ||
<StructureSection load='1n72' size='340' side='right'caption='[[1n72 | <StructureSection load='1n72' size='340' side='right'caption='[[1n72]]' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[1n72]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/ | <table><tr><td colspan='2'>[[1n72]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1b91 1b91]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1N72 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1N72 FirstGlance]. <br> | ||
</td></tr><tr id=' | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1n72 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1n72 OCA], [https://pdbe.org/1n72 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1n72 RCSB], [https://www.ebi.ac.uk/pdbsum/1n72 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1n72 ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1n72 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1n72 OCA], [https://pdbe.org/1n72 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1n72 RCSB], [https://www.ebi.ac.uk/pdbsum/1n72 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1n72 ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
[https://www.uniprot.org/uniprot/KAT2B_HUMAN KAT2B_HUMAN] Functions as a histone acetyltransferase (HAT) to promote transcriptional activation. Has significant histone acetyltransferase activity with core histones (H3 and H4), and also with nucleosome core particles. Also acetylates non-histone proteins, such as ACLY. Inhibits cell-cycle progression and counteracts the mitogenic activity of the adenoviral oncoprotein E1A. In case of HIV-1 infection, it is recruited by the viral protein Tat. Regulates Tat's transactivating activity and may help inducing chromatin remodeling of proviral genes.<ref>PMID:8684459</ref> <ref>PMID:9707565</ref> <ref>PMID:10675335</ref> <ref>PMID:23932781</ref> | |||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: | [[Category: Homo sapiens]] | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: Aggarwal | [[Category: Aggarwal AK]] | ||
[[Category: Carlson | [[Category: Carlson JE]] | ||
[[Category: Dhalluin | [[Category: Dhalluin C]] | ||
[[Category: He | [[Category: He C]] | ||
[[Category: Zeng | [[Category: Zeng L]] | ||
[[Category: Zhou | [[Category: Zhou M-M]] | ||